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Панченко Павел Александрович

Занимаемые должности

Доцент (Кафедра технологии тонкого органического синтеза и химии красителей)

Телефон

8-(499)-978-88-20

E-mail

pavel@muctr.ru

Сайт https://muctr.ru
Уровень образования Высшее
Квалификация

Магистр

Преподаваемые дисциплины

Химия и технология органических красителей

Теория цветности и свойства фотовозбужденных состояний

Учёная степень

Кандидат химических наук

Учёное звание Доцент
Наименование направления подготовки и (или) специальности

Химическая технология и биотехнология

Общий стаж работы 11 лет (с 08.12.2008)
Стаж работы по специальности 11 лет (с 08.12.2008)

Публикации

Chemoselective detection of ag+ in purely aqueous solution using fluorescence "turn-on" probe based on crowm-containing 4-methoxy-1,8-naphthalimide / P. A. Panchenko, A. S. Polyakova, Y. V. Fedorov, O. A. Fedorova // Mendeleev Communications. — 2019. — Vol. 29. — P. 155–157. [ DOI ]

Synthesis, structure and metal ion coordination of novel benzodiazamacrocyclic ligands bearing pyridyl and picolinate pendant side-arms / P. A. Panchenko, A. D. Zubenko, E. Y. Chernikova et al. // New Journal of Chemistry. — 2019. [ DOI ]

Thiourea modified doxorubicin: A perspective ph-sensitive prodrug / O. O. Krasnovskaya, V. M. Malinnikov, N. S. Dashkova et al. // Bioconjugate Chemistry. — 2019. — Vol. 30, no. 3. — P. 741–750. A novel approach to the synthesis of pH-sensitive prodrugs has been proposed: thiourea drug modification. Resulting prodrugs can release the cytotoxic agent and the biologically active 2-thiohydantoin in the acidic environment of tumor cells. The concept of acid-catalyzed cyclization of thioureas to 2-thiohydantoins has been proven using a FRET model. Dual prodrugs of model azidothymidine, cytotoxic doxorubicin, and 2-thiohydantoin albutoin were obtained, which release the corresponding drugs in the acidic environment. The resulting doxorubicin prodrug was tested on prostate cancer cells and showed that the thiourea-modified prodrug is less cytotoxic (average IC50 ranging from 0.5584 to 0.9885 μM) than doxorubicin (IC50 ranging from 0.01258 to 0.02559 μM) in neutral pH 7.6 and has similar toxicity (average IC50 ranging from 0.4970 to 0.7994 μM) to doxorubicin (IC50 ranging from 0.2303 to 0.8110 μM) under mildly acidic conditions of cancer cells. Cellular and nuclear accumulation in PC3 tumor cells of Dox prodrug is much higher than accumulation of free doxorubicin. [ DOI ]

Ultrathin film sensory system based on resonance energy transfer between non-covalently linked fluorophores / A. V. Shokurov, A. V. Alexandrova, I. I. Shepeleva et al. // Mendeleev Communications. — 2019. — Vol. 29. — P. 74–76. For the first time, we developed a proof-of-concept FRET-based sensory ultrathin film system, where planar energy donor and energy acceptor layers are not chemically bound to each other. It was shown that this approach is as feasible as the case of covalently linked FRET-couple. Its implementation opens up possibilities for development of novel sensor devices, where tedious and complicated synthesis of fluorophore couples is not required. Moreover, as was shown earlier, in such systems, FRET efficiency can be fine-tuned by introduction of spacer interlayers18, further improving proposed multilayer design. [ DOI ]

Краунсодержащие производные 4-метокси-1,8-нафталимида в качестве основы для разработки флуоресцентных РЕТ-хемосенсоров на катионы металлов / П. А. Панченко, Н. В. Лейчу, Ю. В. Федоров, О. А. Федорова // Макрогетероциклы. — 2019. [ DOI ]

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