Публикации

Synthesis and biological evaluation of novel dispiro-oxindoles with anticancer activity / M. E. Kukushkin, E. K. Beloglazkina, D. A. Skvortsov et al. // Bioorganic and Medicinal Chemistry.

Ti new organic ligands of the terpyridine series: Modification of gold nanoparticles, preparation of coordination compounds with cu(i), catalysis of oxidation reactions so chemistry of heterocyclic compounds / А. G. Majouga, R. B. Romashkina, A. S. Kashaev et al. // of 2,4-di-tert- butylphenol into 3,3', 5,5'-tetra(tert-butyl) biphenyl-2,2'-diol. TC 1 Z9 1 SN 0009-3122 UT WOS:000288797900006 ER.

A new in vitro screening system for evaluating of anticancer drugs effect / A. Vaneev, E. Lopatuhina, A. Alova et al. // European Biophysics Journal. — 2019. — Vol. 48, no. Suppl. 1. — P. S241–S241.

Binuclear copper complexes with (cucui)-cu-i and cu+1.5cu+1.5 core structures formed in the reactions of 3-(2-methylbutyl)-5-pyridylmethylene-2-thiohydantoin with copper(ii) acetylacetonate and copper(ii) chloride / E. K. Beloglazkina, A. V. Yudina, E. A. Pasanaev et al. // Inorganic Chemistry Communications. — 2019. — Vol. 99. — P. 31–35. [ DOI ]

Binuclear copper complexes with cuicui and cu+1.5cu+1.5 core structures formed in the reactions of 3‑(2‑methylbutyl)‑5‑pyridylmethylene‑2‑thiohydantoin with copper(ii) acetylacetonate and copper(ii) chloride / E. K. Beloglazkina, A. V. Yudina, E. A. Pasanaev et al. // Inorganic Chemistry Communications. — 2019. — Vol. 99. — P. 31–35. [ DOI ]

Conjugates of prostate-specific membrane antigen ligands with antitumor drugs / A. A. Uspenskaya, A. É. Machulkin, A. G. Mazhuga, E. K. Beloglazkina // Pharmaceutical Chemistry Journal. — 2019. — Vol. 53, no. 4. — P. 288–297. [ DOI ]

Copper-promoted c-se cross-coupling of 2-selenohydantoins with arylboronic acids in an open flask / O. Vyhivskyi, E. A. Dlin, A. V. Finko et al. // ACS combinatorial science. — 2019. — Vol. 21, no. 6. — P. 456–464. [ DOI ]

Drug-induced alterations in cancer cell compartments studied by local stiffness measurement via scanning ion-conductance microscopy / V. Kolmogorov, A. Alova, A. Yudina et al. // FEBS open bio. — 2019. — Vol. 9, no. Suppl. 1. — P. 168–168. [ DOI ]

Effect of therapeutic agents on tumor cell compartments studied by local measurement of cell stiffness via scanning ion-conductance microscopy / V. Kolmogorov, A. Alova, A. Yudina et al. // European Biophysics Journal. — 2019. — Vol. 48, no. Suppl. 1. — P. S101–S101.

Electrochemical nanoprobe for label-free and real-time analyses of 3d tumor spheroids / R. Akasov, A. Vaneev, A. Alova et al. // FEBS open bio. — 2019. — Vol. 9, no. Suppl. 1. — P. 387–387. [ DOI ]

First example of [3+2] cycloaddition of azomethine ylides to 5-methylidene-3-phenylhydantoin / M. E. Kukushkin, A. A. Kondratyeva, N. V. Zyk et al. // Russian Chemical Bulletin, International education. — 2019. — Vol. 68, no. 11. — P. 2088–2091.

Intravital microscopy reveals a novel mechanism of nanoparticles excretion in kidney / V. Naumenko, A. Nikitin, K. Kapitanova et al. // Journal of Controlled Release. — 2019. — P. 1–1. Developing nanocarriers that accumulate in targeted organs and are harmlessly eliminated still remains a big challenge. Nanoparticles (NP) biodistribution is governed by their size, composition, surface charge and coverage. The current thinking in bionanotechnology is that renal clearance is limited by glomerular basement membrane pore size (≈6 nm), although there is a growing evidence that NP exceeding the threshold can also be excreted with urine. Here we compare biodistribution of PEGylated 140 nm iron oxide cubes and clusters with a special focus on renal accumulation and excretion. Atomic emission spectroscopy, fluorescent microscopy and magnetic resonance imaging revealed rapid and transient accumulation of magnetic NP in kidney. Using intravital microscopy we tracked in real time NP translocation from peritubular capillaries to basal compartment of tubular cells and subsequent excretion to the lumen within 60 min after systemic administration. Transmission electron microscopy revealed persistence of intact full-sized NP in urine 2 hours post injection. The results suggest that translocation through peritubular endothelium to tubular epithelial cells is an alternative mechanism of renal clearance enabling excretion of NP above glomerular cut-off size. [ DOI ]

Long-term live cells observation of internalized fluorescent fe@c nanoparticles in constant magnetic field / A. Garanina, I. Kireev, O. Zhironkina et al. // Journal of Nanobiotechnology. — 2019. — Vol. 17, no. 1. [ DOI ]

Magnetic nanorods for remote disruption of lipid membranes by non-heating low frequency magnetic field / I. M. Le-Deygen, K. Y. Vlasova, E. O. Kutsenok et al. // Nanomedicine: Nanotechnology, Biology, and Medicine. — 2019. — Vol. 21, no. 102065. — P. 1–10. This work presents direct evidence of disordering of liposomal membranes by magnetic nanoparticles during their exposures to non-heating alternating Extremely Low Frequency Magnetic Field (ELF MF). Changes in the lipid membrane structure were demonstrated by the Attenuated total reflection Fourier Transform Infrared and fluorescence spectroscopy. Specifically, about 50% of hydrophobic chains became highly mobile under the action of ELF MF. Magnetic field-induced increase in the membrane fluidity was accompanied by an increase in membrane permeability and release of solutes entrapped in liposomes. A physical model of this process explaining experimental data is suggested. The obtained results open new horizons for the development of systems for triggered drug release without dangerous heating and overheating of tissues. [ DOI ]

Magnetic and optical properties of gold-coated iron oxide nanoparticles / A. Omelyanchik, M. Efremova, N. Myslitskaya et al. // Journal of Nanoscience and Nanotechnology. — 2019. — Vol. 8, no. 19. — P. 4987–4993. [ DOI ]

Nanoscale bio-imaging with scanning ion conductance microscopy / P. Gorelkin, A. Erofeev, V. Kolmogorov et al. // European Biophysics Journal. — 2019. — Vol. 48, no. Suppl. 1. — P. S157–S157.

Novel 2-aminoimidazole-4-one complexes of copper(ii) and cobalt(ii): synthesis, structural characterization and cytotoxicity / O. O. Krasnovskaya, Y. V. Fedorov, V. M. Gerasimov et al. // Arabian Journal of Chemistry. — 2019. — Vol. 12. — P. 835–846. [ DOI ]

Novel rapid method for evaluating of anticancer drugs effect on tumor cells / A. Vaneev, E. Lopatuhina, A. Alova et al. // FEBS open bio. — 2019. — Vol. 9, no. Suppl. 1. — P. 169–169. [ DOI ]

Prolonged oxygen depletion in microwounded cells of chara corallina detected with novel o2 nanosensors / A. Anna, E. Alexander, G. Petr et al. // Journal of Experimental Botany. — 2019. Primary physicochemical steps in microwounding of plants were addressed using electrochemical nano- and microprobes, with the focus on the role of oxygen in the wounding responses of individual plant cells. The electrochemical measurements of oxygen content were performed with carbon-filled quartz micropipettes having platinum-coated tips (oxygen nanosensors). This novel platinum nanoelectrodes are beneficial for understanding cell oxygen metabolism and can be implemented to study the redox biochemistry and biology of cells, tissues and organisms. We show here that microinjury of Chara corallina internodal cell with a tip of a glass micropipette is associated with a drastic decrease in O2 concentration at the vicinity of the stimulation site. This decrease is reversible and lasts for up to 40 minutes. Membrane stretching, Ca2+ influx and cytoskeleton rearrangements were found to be essential for localized oxygen depletion induced by cell wall microwounding. Inhibition of electron transport in chloroplasts or mitochondria did not affect the magnitude or timing of the observed response. In contrast, the inhibition of NADPH oxidase activity caused significant reduction in the amplitude of the oxygen decrease. We suggest that the discovered creation of localized anoxic conditions in response to cell wall puncture might be mediated by NADPH oxidase. [ DOI ]

Selective deformation of single macromolecules and biomolecular structures as a method for remote control of their properties and functions for next-generation medicine / Y. I. Golovin, N. L. Klyachko, A. O. Zhigachev et al. // Russian Metallurgy (Metally). — 2019. — Vol. 2019, no. 4. — P. 374–384. An innovative nanomechanical strategy for in vivo biomedical applications is reviewed. The strategy is based on the use of complexes of special functionalized magnetic nanoparticles controlled by an external low-frequency nonheating magnetic field as deformation machines. The advantages of the strategy are the possibility of easily achieved nanoscale locality and molecular selectivity of action (at the level of individual macromolecules and macromolecular structures such as liposomes, living cells, cell organelles), multimodality, safety, and a high potential of therapeutic application, in particular, for noninvasive oncotherapy without drugs. [ DOI ]

Stereocontrolled [3+2] cycloaddition of donor–acceptor cyclopropanes to iminooxindoles: Access to spiro[oxindole-3,2′-pyrrolidines] / A. A. Akaev, S. I. Bezzubov, V. G. Desyatkin et al. // Journal of Organic Chemistry. — 2019. — Vol. 84, no. 6. — P. 3340–3356. [ DOI ]

Study of brownian motion of magnetic nanoparticles in viscous media by mössbauer spectroscopy / R. Gabbasov, A. Yurenya, A. Nikitin et al. // Journal of Magnetism and Magnetic Materials. — 2019. — Vol. 475. — P. 146–151. The Mössbauer spectroscopy method was used to study the Brownian motion of magnetic nanoparticles in viscous media of glycerol solution, simulating cell cytoplasm. We used samples of two types of ferrofluids based on the magnetite nanoparticles with average hydrodynamic sizes 140 and 40 nm. The nanoparticles were enriched by 57Fe isotope to compensate the decrease of the Mössbauer effect probability in the liquid media. In order to maximize the viscosity coefficient we dissolved both samples in glycerol to receive more than 90% glycerol solution. We carried out two experimental series at different temperatures on ferrofluids dissolved in glycerol and ferrofluids dried to the powder-state to exclude the influence of the temperature dependent Neel relaxation. The analysis of the spectra allowed us to reveal the Brownian movement of the particles and to evaluate intrinsic dynamical parameters of the model viscous medium. [ DOI ]

Synthesis and biological evaluation of doxorubicin-containing conjugate targeting psma / Y. Ivanenkov, A. Machulkin, A. Garanina et al. // Bioorganic and Medicinal Chemistry Letters. — 2019. — Vol. 29, no. 10. — P. 1246–1255. Prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II (GCPII), has recently emerged as a prominent biomarker of prostate cancer (PC) and as an attractive protein trap for drug targeting. At the present time, several drugs and molecular diagnostic tools conjugated with selective PSMA ligands are actively evaluated in different preclinical and clinical trials. In the current work, we discuss design, synthesis and a preliminary biological evaluation of PSMA-specific small-molecule carrier equipped by Doxorubicin (Dox). We have introduced an unstable azo-linker between Dox and the carrier hence the designed compound does release the active substance inside cancer cells thereby providing a relatively high Dox concentration in nuclei and a relevant cytotoxic effect. In contrast, we have also synthesized a similar conjugate with a stable amide linker and it did not release the drug at all. This compound was predominantly accumulated in cytoplasm and did not cause cell death. Preliminary in vivo evaluation has showed good efficiency for the degradable conjugate against PC3-PIP(PSMA+)-containing xenograft mine. Thus, we have demonstrated that the conjugate can be used as a template to design novel analogues with improved targeting, anticancer activity and lower rate of potential side effects. 3D molecular docking study has also been performed to elucidate the underlying mechanism of binding and to further optimization of the linker area for improving the target affinity. [ DOI ]

Synthesis and mössbauer study of 57fe-based nanoparticles biodegradation in living cells / A. Yurenya, A. Nikitin, A. Garanina et al. // Journal of Magnetism and Magnetic Materials. — 2019. — no. 474. — P. 337–342. Biodegradation of nanoparticles includes the destruction of a stabilizing coating and the accompanying change in interparticle interaction, as well as the direct destruction of the inorganic nuclei of particles. These processes lead to characteristic changes in the shape of the Mössbauer spectra of iron oxide nanoparticles. In this work, we investigated the in vitro biodegradation of 57Fe-based magnetic nanoparticles with the aid of Mössbauer spectroscopy. For this purpose, two types of magnetic nanoparticles enriched with the 57Fe isotope were synthesized. Copolymer Pluronic F-127 and citric acid were used to stabilize nanoparticles in aqueous medium. Moreover, synthesized nanoparticles were analyzed by physicochemical methods and investigated for cytotoxicity. The study of magnetic nanoparticles biodegradation was performed on 4 T1 cell culture (breast cancer). We measured Mössbauer spectra of nanoparticles incubated with 4 T1 cells and spectra of control nanoparticle samples at different conditions. The analysis of spectra was carried out in the many-state relaxation model formalism. The study revealed that after 120-hours incubation of nanoparticles in cells, they did not undergo measurable changes typical of biodegradation processes. Nevertheless, we noted intense intracellular oxidation of ferrous iron of synthesized nanoparticles to the ferric phase. The results obtained indicate the possibility of using the obtained nanoparticles in Mössbauer in vitro studies. [ DOI ]

Synthesis and biological evaluation of psma-targeting paclitaxel conjugates / A. E. Machulkin, D. A. Skvortsov, Y. A. Ivanenkov et al. // Bioorganic and Medicinal Chemistry Letters. — 2019. — Vol. 29, no. 16. — P. 2229–2235. Prostate cancer (PC) is the second most commonly occurring cancer in men. Conventional chemotherapy has wide variety of disadvantages such as high systemic toxicity and low selectivity. Targeted drug delivery is a promising approach to decrease side effects of therapy. Prostate specific membrane antigen (PSMA) is overexpressed in prostate cancer cells while low level of expression is observed in normal cells. In this study we describe the development of Glu-urea-Lys based PSMA-targeting conjugates with paclitaxel. A series of new PSMA targeting conjugates with paclitaxel was designed and synthesized. The cytotoxicity of conjugates was evaluated against prostate (LNCaP, 22Rv1 and PC-3) and non-prostate (Hek293T, VA13, A549 and MCF-7) cell lines. The most promising conjugate 21 was examined in vivo using 22Rv1 xenograft mice model. It demonstrated good efficiency comparable with paclitaxel, while reduced toxicity. 3D molecular docking study was also performed to understand underlying mechanism of binding and further optimization of the linker substructure and conjugates structure for improving the target affinity. These conjugates may be useful for further design of novel PSMA targeting delivery systems for PC. [ DOI ]

Synthesis of 3-(pyridine-2-yl)-4,5-dihydro-1h-pyrazole-1-thiocarboxamides and their copper(ii) complexes / E. K. Beloglazkina, D. D. Korablina, N. I. Vorozhtsov et al. // Arabian Journal of Chemistry. — 2019. — Vol. 12, no. 7. — P. 1050–1060. [ DOI ]

Synthesis of allobetulin-based asialoglycoprotein receptor-targeted glycoconjugates / E. I. Seleznev, E. Y. Yamansarov, E. V. Lopatukhina et al. // Mendeleev Communications. — 2019. — Vol. 29, no. 5. — P. 526–528. New allobetulin conjugates were obtained through its O-esterification with hex-5-ynoic acid followed by [3+2]-cycloaddition with three azido derivatives of N-acetyl-d-galactosamine. The conjugates are non-toxic in micromolar range against hepatocellular carcinoma cell lines and have a high affinity towards the asialoglycoprotein receptor of hepatocytes based on molecular docking and surface plasmon resonance data. [ DOI ]

Synthesis of dispirooxindoles containing n-unsubstituted heterocyclic moieties and study of their anticancer activity / A. A. Beloglazkina, N. A. Karpov, S. R. Mefedova et al. // Russian Chemical Bulletin. — 2019. — Vol. 68, no. 5. — P. 1006–1013. [ DOI ]

Synthesis of ethynyl-3-hydroxyquinoline-4-carboxylic acids / S. Y. Maklakova, A. D. Chuprov, M. P. Mazhuga et al. // Russian Chemical Bulletin. — 2019. — Vol. 68, no. 7. — P. 1460–1461. 3-Hydroxyquinoline-4-carboxylic acids containing ethynyl moiety in the 6th and 8th positions were obtained for the fi rst time. A synthetic approach to aforementioned compounds based on the Sonogashira cross-coupling and the Pfi tzinger reaction was developed. Physicochemical properties of the newly synthesized structures were investigated. [ DOI ]

Synthesis of iron oxide nanorods for enhanced magnetic hyperthermia / A. Nikitin, M. Khramtsov, A. Garanina et al. // Journal of Magnetism and Magnetic Materials. — 2019. — Vol. 469. — P. 443–449. Magnetic hyperthermia is one of the most effective methods for treatment of cancer. In this work we discuss synthesis of magnetic iron oxide nanorods (IONRds) and their application for enhanced magnetic hyperthermia. By microwave irradiation the monodisperse water-soluble IONRds with clear morphology were obtained. Magnetic measurements showed that such IONRds have high value of coercivity (141 Oe). Moreover, hyperthermia experiments with synthesized samples were carried out. At the frequency and field strength of alternating magnetic field (AMF) f=261 kHz H=20 kA m-1 the specific absorption rate (SAR) and intrinsic loss power (ILP) values were equal to 147 W g-1 and 1.4 nHm2 kg-1 respectively, which confirms the efficiency of synthesized nanorods in hyperthermia applications. [ DOI ]

Thiourea modified doxorubicin: A perspective ph-sensitive prodrug / O. O. Krasnovskaya, V. M. Malinnikov, N. S. Dashkova et al. // Bioconjugate Chemistry. — 2019. — Vol. 30, no. 3. — P. 741–750. A novel approach to the synthesis of pH-sensitive prodrugs has been proposed: thiourea drug modification. Resulting prodrugs can release the cytotoxic agent and the biologically active 2-thiohydantoin in the acidic environment of tumor cells. The concept of acid-catalyzed cyclization of thioureas to 2-thiohydantoins has been proven using a FRET model. Dual prodrugs of model azidothymidine, cytotoxic doxorubicin, and 2-thiohydantoin albutoin were obtained, which release the corresponding drugs in the acidic environment. The resulting doxorubicin prodrug was tested on prostate cancer cells and showed that the thiourea-modified prodrug is less cytotoxic (average IC50 ranging from 0.5584 to 0.9885 μM) than doxorubicin (IC50 ranging from 0.01258 to 0.02559 μM) in neutral pH 7.6 and has similar toxicity (average IC50 ranging from 0.4970 to 0.7994 μM) to doxorubicin (IC50 ranging from 0.2303 to 0.8110 μM) under mildly acidic conditions of cancer cells. Cellular and nuclear accumulation in PC3 tumor cells of Dox prodrug is much higher than accumulation of free doxorubicin. [ DOI ]

Visualization and cytotoxicity of fluorescence-labeled dimeric magnetite-gold nanoparticles conjugated with prostate-specific membrane antigen in mouse macrophages / S. K. Pirutin, M. V. Efremova, A. I. Yusipovich et al. // Bulletin of Experimental Biology and Medicine. — 2019. — Vol. 166, no. 3. — P. 386–389. We demonstrated the possibility of penetration of magnetite-gold nanoparticles conjugated with prostate-specific membrane antigen into mouse macrophages. It was found that after 3-h incubation with nanoparticles in a concentration of 15 mg/liter at 37oC, they were seen in only 13% macrophages. In about 90% cells, the nanoparticles were detected within the cytoplasm. Under these conditions, membrane damage was revealed in 25% cells. These results should be taken into account in further development and application of nanomaterials for diagnostic and therapeutic purposes in oncology. [ DOI ]

ИЗУЧЕНИЕ ВЛИЯНИЯ ТЕРАПЕВТИЧЕСКИХ АГЕНТОВ НА РАЗЛИЧНЫЕ КОМПАРТМЕНТЫ ОПУХОЛЕВЫХ КЛЕТОК МЕТОДОМ ЛОКАЛЬНОГО ИЗМЕРЕНИЯ МЕХАНИЧЕСКИХ СВОЙСТВ С ПРИМЕНЕНИЕМ СКАНИРУЮЩЕЙ ИОН-ПРОВОДЯЩЕЙ МИКРОСКОПИИ / В. С. Колмогоров, А. В. Алова, А. С. Юдина и др. // Acta Naturae спецвыпуск. — 2019. — Т. 1, № 2. — С. 246–246. В.С. Колмогоров, А.В. Алова, А.С. Юдина, А.С. Гаранина, А.С. Ерофеев, П.В. Горелкин, Н.Л. Клячко, И.И. Киреев, А.Г. Мажуга, К. Эдвардс, Ю.Е. Корчев, П. Новак (2019). ИЗУЧЕНИЕ ВЛИЯНИЯ ТЕРАПЕВТИЧЕСКИХ АГЕНТОВ НА РАЗЛИЧНЫЕ КОМПАРТМЕНТЫ ОПУХОЛЕВЫХ КЛЕТОК МЕТОДОМ ЛОКАЛЬНОГО ИЗМЕРЕНИЯ МЕХАНИЧЕСКИХ СВОЙСТВ С ПРИМЕНЕНИЕМ СКАНИРУЮЩЕЙ ИОН- ПРОВОДЯЩЕЙ МИКРОСКОПИИ. Acta Naturae, 2019, спецвыпуск, Т.1. НАУЧНЫЕ ТРУДЫ. Том 2. – М.: Издательство Перо, 2019. P. 246. ISBN 978-5-00150-519-8 (Общ.) ISBN 978-5-00150-521-1 (Т.2.) II Объединенный научный форум, включающий VI Cъезд физиологов СНГ, VI Съезд биохимиков России и IX Российский симпозиум Белки и пептиды, Сочи, Дагомыс, 1-6 октября, 2019, Россия.

Конъюгаты на основе лигандов простатического специфического мембранного антигена с противоопухолевыми препаратами / А. А. Успенская, А. Э. Мачулкин, А. Г. Мажуга, Е. К. Белоглазкина // Химико-фармацевтический журнал. — 2019. — Т. 53, № 4. — С. 10–19. [ DOI ]

Получение и тестирование клеток, экспрессирующих флюоресцентные белки, для исследования опухолевого микроокружения методом интравитальной микроскопии / С. С. ВОДОПЬЯНОВ, М. А. КУНИН, А. С. ГАРАНИНА и др. // Клеточные технологии в биологии и медицине. — 2019. — № 1. — С. 3–11. Метод интравитальной микроскопии широко применяется для исследования механизмов канцерогенеза in vivo, а также ответа на противоопухолевую терапию. Для визуализации опухолевых клеток с помощью интравитальной микроскопии используют клеточные линии, экспрессирующие флюоресцентные белки. Экспрессия экзогенных белков может влиять на скорость роста клеток и их туморогенность, поэтому для адекватного моделирования опухолевого микроокружения необходим анализ морфофункциональных свойств трансдуцированных клеточных линий. Методом лентивирусной трансдукции было получено 6 опухолевых линий мыши, экспрессирующих зеленый или красный флюоресцентный белок. Анализ морфологии, скорости роста и чувствительности к химиотерапии in vitro не выявил существенных различий между исходными и трансдуцированными линиями. Включение генов флюоресцентных белков в геном клеток 4T1 (рак молочной железы мыши) и B16-F10 (меланома мыши) не влияло на скорость роста опухолей после подкожного введения животным, однако клетки опухоли толстой кишки мыши CT26-GFP и CT26-RFP отторгались начиная с 8-х суток после имплантации. Изучение механизмов отторжения клеток линий СТ26-GFP/RFP позволит модифицировать методику транcдукции для получения моделей опухолевого микроокружения, доступных для визуализации in vivo. Трансдуцированные клеточные линии 4Т1 и B16-F10 могут применяться для изучения опухолевых клеток, сосудов и субпопуляций лейкоцитов методом интравитальной микроскопии.

Синтез и цитотоксичность новых ацетиленсодержащих производных пентациклических тритерпеноидов / Э. Ю. Ямансаров, И. В. Салтыкова, С. В. Ковалев и др. // Известия Академии наук. Серия химическая, издательство Наука (М.). — 2019. — № 4. — С. 855–861. [ DOI ]

(z)-4-АРИЛИДЕН-1-АРИЛ-2-(АРИЛСЕЛАНИЛ)-1h-ИМИДАЗОЛ-5(4h)-ОНЫ - ПОТЕНЦИАЛЬНЫЕ ИНГИБИТОРЫ АНДРОГЕНОВОГО РЕЦЕПТОРА / Е. А. Длин, С. П. Степанова, А. В. Финько и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 26–27.

A convenient synthesis of copper(ii) bis[5-(pyridin-2-yl-methylidene)-2-thiohydantoin]copmlexes / S. Irina, U. Anna, M. Andrei et al. // Mendeleev Communications. — 2018. — Vol. 28. — P. 524–526. [ DOI ]

Anisotropic iron-oxide nanoparticles for diagnostic mri: synthesis and contrast properties / A. A. Nikitin, M. A. Khramtsov, A. G. Savchenko et al. // Pharmaceutical Chemistry Journal. — 2018. — Vol. 52, no. 3. — P. 231–235. [ DOI ]

Biodistribution and tumors mri contrast enhancement of magnetic nanocubes, nanoclusters, and nanorods in multiple mice models / V. Naumenko, A. Garanina, A. Nikitin et al. // Contrast Media and Molecular Imaging. — 2018. — Vol. 2018. — P. 1–12. Magnetic resonance imaging (MRI) is a powerful technique for tumor diagnostics. Iron oxide nanoparticles (IONPs) are safe and biocompatible tools that can be used for further enhancing MR tumor contrasting. Although numerous IONPs have been proposed as MRI contrast agents, low delivery rates to tumor site limit its application. IONPs accumulation in malignancies depends on both IONPs characteristics and tumor properties. In the current paper, three diŽerently shaped Pluronic F127-modi’ed IONPs (nanocubes, nanoclusters, and nanorods) were compared side by side in three murine tumor models (4T1 breast cancer, B16 melanoma, and CT26 colon cancer). Orthotopic B16 tumors demonstrated more ecient IONPs uptake than heterotopic implants. Magnetic nanocubes (MNCb) had the highest r2-relaxivity in vitro (300 mM−1·s−1) compared with magnetic nanoclusters (MNCl, 104 mM−1·s−1) and magnetic nanorods (MNRd, 51 mM−1·s−1). As measured by atomic emission spectroscopy, MNCb also demonstrated better delivery eciency to tumors (3.79% ID) than MNCl (2.94% ID) and MNRd (1.21% ID). Nevertheless, MNCl overperformed its counterparts in tumor imaging, providing contrast enhancement in 96% of studied malignancies, whereas MNCb and MNRd were detected by MRI in 73% and 63% of tumors, respectively. Maximum MR contrasting eciency for MNCb and MNCl was around 6-24 hours after systemic administration, whereas for MNRd maximum contrast enhancement was found within ’rst 30 minutes upon treatment. Presumably, MNRd poor MRI performance was due to low r2-relaxivity and rapid clearance by lungs (17.3% ID) immediately after injection. MNCb and MNCl were mainly captured by the liver and spleen without signi’cant accumulation in the lungs, kidneys, and heart. High mbiocompatibility and profound accumulation in tumor tissues make MNCb and MNCl the promising platforms for MRI-based tumor diagnostics and drug delivery. [ DOI ]

Cинтез и исследование цитотоксичности новых диспиропроизводных 5-арилиденоксазолонов — потенциальных ингибиторов белок-белкового взаимодействия p53—mdm2 / А. A. Белоглазкина, Д. А. Скворцов, В. А. Тафеенко и др. // Известия Академии наук. Серия химическая. — 2018. — № 3. — С. 562–569.

Design of conductive microwire systems for manipulation of biological cells / A. Omelyanchik, E. Levada, J. Ding et al. // IEEE Transactions on Magnetics. — 2018. — Vol. 54, no. 6. — P. 1–5. [ DOI ]

Effect of iron oxide nanoparticle shape on doxorubicin drug delivery toward lncap and pc-3 cell lines / T. R. Nizamov, A. S. Garanina, I. S. Grebennikov et al. // BioNanoScience. — 2018. — Vol. 8, no. 1. — P. 394–406. [ DOI ]

Hsa—coated magnetic nanoparticles for mri-guided photodynamic cancer therapy / P. Ostroverkhov, A. Semkina, V. Naumenko et al. // Pharmaceutics. — 2018. — Vol. 10, no. 4. — P. 284. [ DOI ]

In situ observation of chymotrypsin catalytic activity change actuated by nonheating low-frequency magnetic field / M. V. Efremova, M. M. Veselov, A. V. Barulin et al. // ACS Nano. — 2018. — Vol. 12, no. 4. — P. 3190–3199. [ DOI ]

Magnetite-gold nanohybrids as ideal all-in-one platforms for theranostics / M. V. Efremova, V. A. Naumenko, M. Spasova et al. // Scientific reports. — 2018. — Vol. 8, no. 11295. [ DOI ]

Nanopipette navigation system as a new tool for nanoscale investigation of living cells / P. Gorelkin, A. Erofeev, A. Alova et al. // FEBS open bio. — 2018. — Vol. 8. — P. 480. [ DOI ]

New approaches to nanotheranostics: Polyfunctional magnetic nanoparticles activated by non-heating low-frequency magnetic field control biochemical system with molecular locality and selectivity / Y. I. Golovin, N. L. Klyachko, A. G. Majouga et al. // Nanotechnologies in Russia. — 2018. — Vol. 13, no. 5-6. — P. 215–239. Golovin Y.I., Klyachko N.L.*, Majouga A.G., Gribanovsky S.L., Golovin D.Y., Zhigachev A.O., Shuklinov A.V., Efremova M.V., Veselov M.M., Vlasova K.Yu., Usvaliev A.D., Le-Deygen I.M., Kabanov A.V. (2018). New Approaches to Nanotheranostics: Polyfunctional Magnetic Nanoparticles Activated by Non-Heating Low-Frequency Magnetic Field Control Biochemical System with Molecular Locality and Selectivity. Nanotechnologies in Russia. V. 13. No. 5–6. P. 215–239 In this work, a novel approach to magnetic nanotheranostics based on the activation of magnetic nanoparticles (MNPs) with a nonheating low-frequency magnetic field has been described. Electromagnetic biomedical technologies implemented in low-frequency nonheating and radiofrequency heating magnetic fields have been briefly reviewed and compared. It has been shown that the activation of MNPs with nonheating magnetic fields has several advantages over activation with heating magnetic fields, namely, a more universal character and penetration ability into tissues, easy dosing and control, higher locality and safety, molecular selectivity, and lower cost. A combination of methods developed and patented by us can form a technological platform for new-generation low-frequency magnetic theranostics which is significantly more effective and possesses more options than conventional radiofrequency theranostics. DOI: 10.1134/S1995078018030060. [ DOI ]

New ferrocene-based 2-thio-imidazol-4-ones and their copper complexes. synthesis and cytotoxicity / D. A. Guk, O. O. Krasnovskaya, N. S. Dashkova et al. // Dalton Transactions. — 2018. — Vol. 47. — P. 17357–17366. Synthesis, characterization (HRMS, NMR, EPR, XANES, UV-Vis spectroscopy, and electrochemistry), DNA and BSA binding and in vitro biological screening of two new ferrocene-incorporated thiohydantoin derivatives (5 and 6) and their copper coordination compounds are reported. The ferrocene-based thiohydantoin derivatives were prepared by copper-catalyzed azide alkyne cycloaddition reactions between alkynyl ferrocenes and 5-(Z)-3-(2-azidoethyl)-2-(methylthio)-5-(pyridin-2-ylmethylene)-1H-imidazol-4H-one. Alkynyl ferrocenes necessary for these syntheses were prepared by new procedures. Intermolecular redox reactions between the ferrocene fragment and copper(+2) coordinated ions were studied by different methods to determine the mechanism and kinetic constants of redox processes. Ferrocene-containing imidazolones (5 and 6) and their copper complexes were also tested for their in vitro cytotoxic activity against MCF-7 and A-549 carcinoma cells, and also against the noncancerous cell line Hek-293. The results showed modest cytotoxicity against the subjected cancer cell line compared with cisplatin. The ability of the obtained compounds to cause DNA degradation and cell apoptosis was investigated, and the distribution of cytosol/pellets was studied by AAS. [ DOI ]

New superparamagnetic fluorescent fe@c-c5on2h10-alexa fluor 647 nanoparticles for biological applications / A. S. Garanina, I. I. Kireev, I. B. Alieva et al. // Наносистемы: физика, химия, математика. — 2018. — Vol. 9, no. 1. — P. 1–3. The structure and physical properties of superparamagnetic Fe@C nanoparticles (Fe@C NPs) as well as their uptake by living cells and behavior inside the cell were investigated. Magnetic capacity of Fe@C NPs was compared with Fe7C3@C NPs investigated in our previous work, and showed higher value of magnetic saturation, 75 emu.g−1(75 Am 2·kg−1), against 54emu.g−1(54 Am 2·kg−1) for Fe7C3@C. The surface of Fe@C NPs was alkylcarboxylated and further aminated for covalent linking to the molecules of fluorochrome Alexa Fluor 647. Fluorescent Fe@C-C5ON2H10-Alexa Fluor 647 NPs (Fe@C-Alexa NPs) were incubated with HT1080 human fibrosarcoma cells and investigated using fluorescent, confocal laser scanning and transmission electron microscopy. No toxic effect on the cell physiology was observed. In a magnetic field, the NPs became aligned along the magnetic lines inside the cells.

Novel method for rapid toxicity screening of magnetic nanoparticles / A. Erofeev, P. Gorelkin, A. Garanina et al. // Scientific reports. — 2018. — Vol. 8, no. 1. Iron oxide nanoparticles have attracted a great deal of research interest and have been widely used in bioscience and clinical research including as contrast agents for magnetic resonance imaging, hyperthermia and magnetic field assisted radionuclide therapy. It is therefore important to develop methods, which can provide high-throughput screening of biological responses that can predict toxicity. The use of nanoelectrodes for single cell analysis can play a vital role in this process by providing relatively fast, comprehensive, and cost-effective assessment of cellular responses. We have developed a new method for in vitro study of the toxicity of magnetic nanoparticles (NP) based on the measurement of intracellular reactive oxygen species (ROS) by a novel nanoelectrode. Previous studies have suggested that ROS generation is frequently observed with NP toxicity. We have developed a stable probe for measuring intracellular ROS using platinized carbon nanoelectrodes with a cavity on the tip integrated into a micromanipulator on an upright microscope. Our results show a significant difference for intracellular levels of ROS measured in HEK293 and LNCaP cancer cells before and after exposure to 10 nm size iron oxide NP. These results are markedly different from ROS measured after cell incubation with the same concentration of NP using standard methods where no differences have been detected. In summary we have developed a label-free method for assessing nanoparticle toxicity using the rapid (less than 30 minutes) measurement of ROS with a novel nanoelectrode. [ DOI ]

Separation of β-blocker enantiomers on silica modified with gold nanoparticles with immobilized macrocyclic antibiotic vancomicin / I. A. Ananieva, Y. A. Polyakova, E. N. Shapovalova et al. // Journal of Analytical Chemistry. — 2018. — Vol. 73, no. 2. — P. 162–169. A new chiral sorbent based on mercaptosilica modified by gold nanoparticles, then treated by 3- mercaptopropionic acid and macrocyclic antibiotic vancomycin, was obtained. The enantioseparation of iso- meric β-blockers (nadolol, atenolol, metoprolol, alprenolol, oxprenolol, and pindolol) by HPLC was studied on the synthesized sorbent. The effect of the composition of the mobile phase (nature and concentration of the organic solvent, concentration and pH of the buffer solution) on retention times of β-blocker enantio- mers, selectivity of separation, and resolution of chromatographic peaks were studied. The best separation was achieved for pindolol and metoprolol. The procedure was used to determine the pindolol enantiomers in the preparation “Visken”, and metoprolol in the “Vazocardin” preparation. [ DOI ]

Size-selected fe3o4–au hybrid nanoparticles for improved magnetism-based theranostics / M. V. Efremova, Y. A. Nalench, E. Myrovali et al. // Beilstein journal of nanotechnology. — 2018. — Vol. 9. — P. 2684–2699. [ DOI ]

Smart nanopipette for single cell analysis / A. Erofeev, P. Gorelkin, A. Garanina et al. // FEBS open bio. — 2018. — Vol. 8. — P. 480–481. [ DOI ]

Synthesis and biological evaluation of novel mono- and bivalent asgp-r-targeted drug-conjugates / R. A. Petrov, S. Y. Maklakova, Y. A. Ivanenkov et al. // Bioorganic and Medicinal Chemistry Letters. — 2018. — Vol. 28, no. 3. — P. 382–387. Asialoglycoprotein receptor (ASGP-R) is a promising biological target for drug delivery into hepatoma cells. Nevertheless, there are only few examples of small-molecule conjugates of ASGP-R selective ligand equipped by a therapeutic agent for the treatment of hepatocellular carcinoma (HCC). In the present work, we describe a convenient and versatile synthetic approach to novel mono- and multivalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose and anticancer drug – paclitaxel (PTX). Several molecules have demonstrated high affinity towards ASGP-R and good stability under physiological conditions, significant in vitro anticancer activity comparable to PTX, as well as good internalization via ASGP-R-mediated endocytosis. Therefore, the conjugates with the highest potency can be regarded as a promising therapeutic option against HCC. [ DOI ]

Synthesis and biological evaluation of novel doxorubicin-containing asgp-r-targeted drug-conjugates / Y. A. Ivanenkov, A. G. Majouga, R. A. Petrov et al. // Bioorganic and Medicinal Chemistry Letters. — 2018. — Vol. 28, no. 3. — P. 503–508. Asialoglycoprotein receptor (ASGP-R) belongs to a wide family of C-type lectins and it is currently regarded as an attractive protein in the field of targeted drug delivery (TDD). It is abundantly expressed in hepatocytes and can be found predominantly on the sinusoidal surface especially of HepG2 cells. Therefore, ASGP-R can be used for the TDD of anticancer therapeutics against HCC and molecular diagnostic tools. To date, a variety of mono- and multivalent selective ASGP-R ligands have been discovered. Although many of these compounds have demonstrated a relatively high binding affinity towards the target, the reported synthetic schemes are not handled, complicated and include many non-trivial steps. In the current study, we describe a convenient and versatile synthetic approach to novel monovalent drug-conjugates containing N-acetyl-2-deoxy-2-aminogalactopyranose fragment as an ASGP-R-recognition “core-head” and well-known nonselective cytostatic – Doxorubicin (Dox). This is the first example of the direct conjugation of a drug molecule to the ASGP-targeted warhead by a really convenient manner via a simple linker sequence. The performed MTS-based biological evaluation in HepG2 cells revealed the novel conjugates as having anticancer activity. Confocal microscopy showed that the molecules readily penetrated HepG2 membrane and were mainly localized within the cytoplasm instead of the nucleus. Per contra, Dox under the same conditions demonstrated good anticancer activity and was predominantly concentrated in the nucleus. Therefore, we speculate that the amide “trigger” that we have used in this study for linker attachment is a sufficiently stable inside the cells to be enzymatically or spontaneously degraded. As a consequence, we did not observe the release of the drug. Ligands containing triggers that are more liable towards endogenous hydrolysis within the tissue of targeting are strongly required. [ DOI ]

Synthesis and characterization of bacteriochlorin loaded magnetic nanoparticles (mnp) for personalized mri guided photosensitizers delivery to tumor / P. V. Ostroverkhov, A. S. Semkina, V. A. Naumenko et al. // Journal of Colloid and Interface Science. — 2018. — Vol. 537. — P. 132–141. [ DOI ]

Synthesis of psma-targeted 13- and 15-substituted chlorin e6 derivatives and their biological properties / N. V. Suvorov, A. E. Machulkin, A. V. Ivanova et al. // Journal of Porphyrins and Phthalocyanines. — 2018. — Vol. 22, no. 11. — P. 1030–1038. [ DOI ]

Synthesis of iron oxide nanoclusters by thermal decomposition / A. A. Nikitin, I. V. Shchetinin, N. Y. Tabachkova et al. // Langmuir : the ACS journal of surfaces and colloids. — 2018. — Vol. 34, no. 15. — P. 4640–4650. Herein, we report a novel one-step solvothermal synthesis of magnetite nanoclusters (MNCs). In this report we discuss synthesis, structure and properties of MNCs and contrast enhancement in T2-weighted MR images using magnetite nanoclusters. Effect of different organic acids, used as surfactants, on size and shape of MNC was investigated. Structure and properties of samples were determined by magnetic measurements, TGA, TEM, HRTEM, XRD, FTIR, MRI. Magnetic measurements show that obtained MNCs have relatively high saturation magnetization values (65.1 – 81.5 emu/g) and dependence of the coercive force on the average size of MNCs was established. MNCs were transferred into aqueous medium by Pluronic F-127 and T2-relaxivity values were determined. T2-weighted MR phantom images clearly demonstrated that such magnetite nanoclusters can be used as contrast agents for MRI. [ DOI ]

Synthesis, characterization and cytotoxicity of binuclear copper(ii) complexes with tetradentate nitrogen-containing ligands bis-5-(2-pyridylmethylidene)-3,5-dihydro-4h-imidazol-4-ones / E. K. Beloglazkina, O. O. Krasnovskaya, D. A. Guk et al. // Polyhedron. — 2018. — Vol. 148. — P. 129–137. A treatment of the N4-type organic ligands containing two 5-(2-pyridylmethylidene)-2-thio-3,5-dihydro-4H-imidazol-4-one fragments linked by (CH2)2 bridges between the sulfur atoms with CuCl2. affords to binuclear copper(II) complexes of corresponding ligands. A series of copper complexes with L(CuCl2)2 composition were isolated and characterized by elemental analysis, UV-vis spectra and cyclic voltammetry; the X-ray crystal structures of four synthesized complexes showed the distored tetrahedral environment of both copper atoms; Cu-Cu distances is about 4.5 Å, which is confirming the absence of interaction between copper ions. Electrochemical studies of complexes demonstrated the simultaneous reduction of each of the coordinated copper atoms at a potential of +0.39–+0.43 V. [ DOI ]

Ways and methods for controlling biomolecular structures using magnetic nanoparticles activated by an alternating magnetic field / Y. I. Golovin, A. O. Zhigachev, M. V. Efremova et al. // Nanotechnologies in Russia. — 2018. — Vol. 13, no. 5-6. — P. 295–304. Yu.I. Golovin, A.O. Zhigachev, M.V. Efremova, A.G. Majouga, A.V. Kabanov, N.L. Klyachko (2018). Ways and Methods for Controlling Biomolecular Structures Using Magnetic Nanoparticles Activated by an Alternating Magnetic Field. Nanotechnologies in Russia. Vol. 13. No. 5–6. P. 295–304. Functionalized magnetic nanoparticles (MNPs) controlled by an external magnetic field provide a new generation of promising nanobiomedical platform. Due to their ability to locally change the state of a biochemical system through two physical processes—thermal and nanomagnetomechanical—they are already used in experiments on targeted drug delivery and therapy of oncological diseases. This work considers the peculiarities, advantages, and disadvantages of each of these processes and the main parameters of the magnetic field defining the action mechanism of MNPs on different biomolecular targets. A brief review and comparative analysis of main experimental studies carried out in the slope of magnetic hyperthermia and nanomagnetomechanical actuation are carried out. DOI: 10.1134/S1995078018030072. [ DOI ]

Визуализация и цитотоксичность флюоресцентно-меченных димерных наночастиц магнетит-золото, конъюгированных с лигандом простатического специфического мембранного антигена, в макрофагах мыши / С. К. Пирутин, М. В. Ефремова, А. И. Юсипович и др. // Бюллетень экспериментальной биологии и медицины. — 2018. — Т. 166, № 9. — С. 362–365. Показана возможность проникновения флюоресцентно-меченных димерных наночастиц магнетит-золото, конъюгированных с лигандом простатического специфического мембранного антигена, в макрофаги мыши. Установлено, что после 3-часовой инкубации клеток с наночастицами в концентрации 15 мкг/мл при 37оС только 13% клеток из всей популяции макрофагов связываются с ними. При этом у около 90% таких клеток наночастицы выявляются внутри цитоплазмы. При таких условиях инкубации обнаруживается около 25% клеток с поврежденной мембраной в результате цитотоксического действия наночастиц. Полученные результаты следует учитывать при применении разработки наноматериалов в диагностике и терапии онкологических заболеваний.

ИЗУЧЕНИЕ ВЛИЯНИЯ РАЗМЕРА ИММОБИЛИЗОВАННЫХ НАНОЧАСТИЦ fe3o4@au ТИПА МАГНЕТИТ@ЗОЛОТО НА ФЕРМЕНТАТИВНУЮ АКТИВНОСТЬ ФЕРМЕНТА ФЕНИЛАЦЕТОН МОНООКСОГЕНАЗЫ / М. А. Тагирова, М. М. Веселов, М. В. Ефремова и др. // Актуальная биотехнология. — 2018. — № 3 (26). — С. 162–163.

ИССЛЕДОВАНИЕ АНТИОКСИДАНТНОЙ АКТИВНОСТИ ЭТИЛ-2-(3-АРИЛСЕЛЕНОМОЧЕВИНЫ)АЦЕТАТОВ И (z)-5-АРИЛИДЕН-3-АРИЛ-2-СЕЛЕНОКСОИМИДАЗОЛИН-4-ОНОВ / С. П. Степанова, Е. А. Длин, А. В. Финько и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 69–69.

Изучение эффективности контрастирования различных видов опухолей с использованием кубических наночастиц магнетита / А. А. Никитин, В. А. Науменко, С. С. Водопьянов и др. // Бюллетень сибирской медицины/Bulletin of Siberian medicine. — 2018. — Т. 17, № 1. — С. 131–139. [ DOI ]

Лиганды асиалогликопротеинового рецептора, содержащие производные дофамина для модификации наночастиц магнетита / О. Н. Метелкина, И. В. Салтыкова, Г. Э. Павловская и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2018. — Т. 17. — С. 45–46.

Липидоподобные наночастицы оксида железа как платформа для доставки нуклеиновых кислот в печень / В. И. Уварова, Т. Р. Низамов, М. А. Абакумов и др. // Вестник Российского государственного медицинского университета. — 2018. — № 6. — С. 43–52. Адресная доставка антисмысловых препаратов является перспективной технологией, на основе которой возможна разработка высокоэффективных лекарственных средств для терапии широкого спектра заболеваний. Однако недостаточная стабильность РНК в биологических средах и гидрофильность, ограничивающая проникновение через клеточные мембраны, существенно сужают их использование в клинической практике. Целью исследования была разработка средств доставки антисмысловых препаратов в гепатоциты печени с помощью липидоподобных магнитных наночастиц (ЛНЧ). Кубические магнитные наночастицы (НЧ) со средними размерами 16 и 27 нм синтезировали методом высокотемпературного разложения прекурсора — олеата железа (III) и химически модифицировали формуляцией, включающей катионный липидоид С12-200. Магнитные НЧ обладают хорошими МРТ-контрастными свойствами, биораспределение ЛНЧ исследовали in vivo на линейных мышах BALB/c с помощью МР-томографа. С этой же целью провели последующее гистологическое исследование срезов печени. Наночастицы меньшего размера не продемонстрировали цитотоксического действия по отношению к клеточным линиям HepG2 и Huh7, а для НЧ кубической формы большего размера IC составила 21,5 мкг/мл для HepG2 и 126 мкг/мл для Huh7. Выявлено, что НЧ меньшего размера аккумулируются преимущественно в гепатоцитах печени, а НЧ большего размера — в селезенке, в печени же они накапливаются главным образом в макрофагах. Такая разница может быть вызвана большим гидродинамическим размером НЧ, которые имеют больший размер магнитного ядра. Образец с ядром меньшего размера является наиболее эффективной платформой для доставки антисмысловых препаратов в гепатоциты. [ DOI ]

МАГНИТНО-РЕЗОНАНСНАЯ ТОМОГРАФИЯ ДЛЯ ПЕРСОНАЛИЗИРОВАННОЙ ОЦЕНКИ И ПРОГНОЗИРОВАНИЯ ЭФФЕКТИВНОСТИ ДОСТАВКИ НАНОФОРМУЛЯЦИЙ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВ / В. А. Науменко, А. С. Гаранина, С. С. Водопьянов и др. // Вестник Российского государственного медицинского университета. — 2018. — № 6. — С. 22–26. Магнитно-резонансная томография (МРТ) широко используется для диагностики онкологических заболеваний, а также для исследования доставки препаратов на магнитных наноносителях. Накопление наночастиц в опухоли высоко вариабельно в популяции и зависит от биологических факторов, которые во многом остаются неизученными. В последние годы было высказано предположение о возможности использования МРТ для предсказания ответа на терапию наноформулированными препаратами на основе скрининговых данных о накоплении в опухоли магнитноконтрастных диагностикумов. Несмотря на то что пилотные испытания указывают на принципиальную возможность предложенного подхода, существует ряд концептуальных проблем и технических ограничений для внедрения технологии в клинику. В статье обсуждаются преимущества и недостатки методов, позволяющих стратифицировать опухоли по степени накопления наночастиц. Дальнейшие исследования в данной области позволят разработать эффективные алгоритмы индивидуального лечения противоопухолевыми препаратами, доставляемыми на наночастицах. [ DOI ]

Новые подходы к нанотераностике: полифункциональные магнитные наночастицы, активируемые негреющим низкочастотным магнитным полем, управляют биохимической системой с молекулярной локальностью и селективностью / Ю. И. Головин, Н. Л. Клячко, А. Г. Мажуга и др. // Российские нанотехнологии. — 2018. — Т. 13, № 5-6. — С. 3–25.

Новые рН-чувствительные производные тиомочевины как диагностические и цитостатические препараты / В. М. Малинников, О. О. Красновская, Е. К. Белоглазкина и др. // Российский биотерапевтический журнал. — 2018. — Т. 17, № S. — С. 43–44.

Новые цитотоксичные координационные соединения cu (ii/i), fe (iii/ii) как противоопухолевые терапевтические агенты / Д. А. Гук, О. О. Красновская, Е. К. Белоглазкина и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 24–24.

Определение активных форм кислорода в биологических жидкостях с помощью платинового наноэлектрода амперометрическим методом / А. Н. Ванеев, A. В. Алова, А. С. Ерофеев и др. // Вестник Российского государственного медицинского университета. — 2018. [ DOI ]

Пути и методы управления биомолекулярными структурами с помощью магнитных наночастиц, активируемых переменным магнитным полем / Ю. И. Головин, А. О. Жигачев, М. В. Ефремова и др. // Российские нанотехнологии. — 2018. — Т. 13, № 5-6. — С. 82–90.

РАЗДЕЛЕНИЕ ЭНАНТИОМЕРОВ β-БЛОКАТОРОВ НА СИЛИКАГЕЛЕ, МОДИФИЦИРОВАННОМ НАНОЧАСТИЦАМИ ЗОЛОТА С ИММОБИЛИЗОВАННЫМ МАКРОЦИКЛИЧЕСКИМ АНТИБИОТИКОМ ВАНКОМИЦИНОМ / И. А. Ананьева, Я. А. Полякова, Е. Н. Шаповалова и др. // Журнал аналитической химии. — 2018. — Т. 73, № 2. — С. 113–120. Получен новый хиральный сорбент на основе меркаптосиликагеля, модифицированного наночасти- цами золота, с последующей их обработкой 3-меркаптопропионовой кислотой и макроциклическим антибиотиком ванкомицином. Исследовано энантиоразделение изомеров β-блокаторов (надолол, атенолол, метопролол, алпренолол, окспренолол, пиндолол) на синтезированном сорбенте методом ВЭЖХ. Изучены влияние состава подвижной фазы (природа и содержание органического раствори- теля, концентрация и рН буферного раствора) на времена удерживания энантиомеров β-блокаторов, селективность разделения и разрешение хроматографических пиков. Лучшее разделение достигнуто для пиндолола и метопролола. Методика применена для определения энантиомеров пиндолола в пре- парате “Вискен” и метопролола в препарате “Вазокардин”. [ DOI ]

Разработка новых потенциальных противоопухолевых препаратов – производных и спиро- и спироиндолинонов / В. К. Новоторцев, М. Е. Кукушкин, А. Г. Мажуга и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 53.

СИНТЕЗ И БИОЛОГИЧЕСКИЕ ИСПЫТАНИЯ КОНЪЮГАТОВ ПАКЛИТАКСЕЛА НА ОСНОВЕ ИНГИБИТОРА ПРОСТАТИЧЕСКОГО СПЕЦИФИЧЕСКОГО МЕМБРАННОГО АНТИГЕНА ДЛЯ ТЕРАПИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ / А. П. БЕР, А. Э. МАЧУЛКИН, М. В. КОВАЛЬЧУК и др. // Российский биотерапевтический журнал. — 2018. — Т. 17, № S. — С. 7–8.

СИНТЕЗ И БИОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВ НАПРАВЛЕННОГО ДЕЙСТВИЯ НА ОСНОВЕ ЛИГАНДОВ asgpr / А. Д. Чупров, С. Ю. Маклакова, В. В. Гопко и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2018. — Т. 17, № S1. — С. 83–83.

СИНТЕЗ НОВОГО ТРИВАЛЕНТНОГО ЛИГАНДА asgp-РЕЦЕПТОРА НА ОСНОВЕ n-АЦЕТИЛГАЛАКТОЗАМИНА / Г. С. Решитько, Д. О. Шкиль, Э. Ю. Ямансаров и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2018. — Т. 17. — С. 62–62.

СИНТЕЗ НОВЫХ ГЛИКОКОНЪЮГАТОВ АЛЛОБЕТУЛИНА И n-АЦЕТИЛГАЛАКТОЗАМИНА / Е. И. Селезнев, Э. Ю. Ямансаров, Р. А. Петров и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2018. — Т. 17. — С. 65–66.

Селективное деформирование одиночных макромолекул и биомолекулярных структур как метод дистанционного управления их свойствами и функциями в интересах медицины нового поколения / Ю. И. Головин, Н. Л. Клячко, А. О. Жигачев и др. // Деформация и разрушение материалов. — 2018. — № 12. — С. 12–22. В обзоре рассмотрена инновационная наномеханомагнитная стратегия для in vivo биомедицинских приложений, основанная на применении в качестве деформационных машин комплексов из специальных функционализованных магнитных наночастиц, управляемых внешним низкочастотным негреющим магнитным полем. Преимущества этой стратегии заключаются в возможности легкого достижения наномасштабной локальности и молекулярной селективности воздействия (на уровне отдельных макромолекул и макромолекулярных структур, таких как липосомы, живые клетки и клеточные органеллы), мультимодальности, безопасности и большом потенциале ее терапевтического применения, в частности, для безлекарственной, неинвазивной онкотерапии. [ DOI ]

Синтез и биологические исследования лекарственных средств на основе диспиропроизводных для терапии раковых заболеваний / Н. А. Карпов, С. Р. Мефёдова, А. А. Белоглазкина и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 33.

Синтез и биологическое исследование производных 2-тиогидантоина – ингибиторов андрогенового рецептора / Г. М. Аверочкин, А. И. Соколов, А. А. Выговский и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 2–2.

Синтез и исследование в качестве потенциальных противоопухолевых агентов новых структурных типов спиро-и диспироиндолинонов / В. Е. Филатов, В. К. Новоторцев, М. Е. Кукушкин и др. // Российский биотерапевтический журнал. — 2018. — Т. 17. — С. 75.

2-guanidino-quinazolines as a novel class of translation inhibitors / E. S. Komarova Andreyanova, I. A. Osterman, P. I. Pletnev et al. // Biochimie. — 2017. — Vol. 133. — P. 45–55. A variety of structurally unrelated organic compounds has been reported to have antibacterial activity. Among these, certain small-molecule translation inhibitors have attracted a great deal of attention, due to their relatively high selectivity against prokaryotes, and an appropriate therapeutic index with minor “off target” effects. However, ribosomes are being considered as poorly druggable biological targets, thereby making some routine computational-based approaches to rational drug design and its development rather ineffective. Taking this into account, diversity-oriented biological screening can reasonably be considered as the most advantageous strategy. Thus, using a high-throughput screening (HTS) platform, we applied a unique biological assay for in vitro evaluation of thousands of organic molecules, especially targeted against bacterial ribosomes and translation. As a result, we have identified a series of structurally diverse small-molecule compounds that induce a reporter strain sensitive to translation and DNA biosynthesis inhibitors. In a cell free system, several molecules were found to strongly inhibit protein biosynthesis. Among them, compounds bearing a 2-guanidino-quinazoline core demonstrated the most promising antibacterial activity. With regard to the preliminary structure–activity relationship (SAR) study, we revealed that relatively small substituents at positions 4, 6 and 8 of the quinazoline ring significantly enhance the target activity whereas modification of the guanidine group leads to decrease or loss of antibacterial potency. This novel class of translation inhibitors can properly be regarded as a promising starting point for the development of novel antibacterial therapeutic or screening tools. [ DOI ]

3-(2-azidoethyl)oxindoles: Advanced building blocks for one-pot assembly of spiro[pyrrolidine-3,3’-oxindoles] / A. A. Akaev, E. V. Villemson, N. S. Vorobyeva et al. // Journal of Organic Chemistry. — 2017. — Vol. 82, no. 11. — P. 5689–5701. [ DOI ]

Automated solid phase click synthesis of oligonucleotide conjugates: from small molecules to diverse n-acetylgalactosamine clusters / V. M. Farzan, E. A. Ulashchik, Y. V. Martynenko-Makaev et al. // Bioconjugate Chemistry. — 2017. We developed a novel technique for efficient conjugation of oligonucleotides with various alkyl azides (fluorescent dyes, biotin, cholesterol, GalNAc, etc.) using CuAAC on solid phase and CuI·P(OEt)3 as a catalyst. Conjugation is carried out in an oligonucleotide synthesizer in fully automated mode and is coupled to oligonucleotide synthesis and on-column deprotection. We also suggest a set of reagents for the construction of diverse conjugates. The sequential double click procedure using a pentaerythritol-derived tetraazide followed by the addition of a GalNAc or tris-GalNAc alkyne gives oligonucleotide-GalNAc dendrimer conjugates in good yields with minimal excess of sophisticated alkyne reagents. The approach is suitable for high throughput synthesis of oligonucleotide conjugates, ranging from fluorescent DNA probes to various multi-GalNAc derivatives of 2′-modified siRNA. [ DOI ]

Discovery of a novel series of tankyrase inhibitors by a hybridization approach / R. A. Upendra, J. Waaler, N. Yves et al. // Journal of Medicinal Chemistry. — 2017.

Experimental approaches to the development of systems for targeted drug delivery to liver cells / Y. A. Ivanenkov, S. Y. Maklakova, E. K. Beloglazkina et al. // Russian Chemical Reviews. — 2017. — Vol. 86, no. 8. — P. 750–776. [ DOI ]

Human health as a multidimensional phenomenon: approaches to study and phenomenology / A. G. Madzhuga, P. A. Kislyakov, A. R. Sadykova et al. // Multidisciplinary Journal of Science & Research. – www.pontejournal.net. — 2017. — Vol. 73, no. 9. — P. pp. 27–42.

Modeling drug release from functionalized magnetic nanoparticles actuated by non-heating low frequency magnetic field / Y. Golovin, D. Golovin, N. Klyachko et al. // Journal of Nanoparticle Research. — 2017. — Vol. 19, no. 2. — P. 64. [ DOI ]

Nanoscale engineering of hybrid magnetite-carbon nanofibre materials for magnetic resonance imaging contrast agents / O. N. Metelkina, R. W. Lodge, P. G. Rudakovskaya et al. // Journal of Materials Chemistry С. — 2017. — Vol. 5. — P. 2167–2174.

New copper thiohydantoin complexes: Synthesis, characterization, and assessment of their interaction with bovine serum albumin and dna / T. Ksenia, B. Elena, P. Mikhail et al. // Journal of Inorganic Biochemistry. — 2017. — Vol. 175. — P. 190–197. [ DOI ]

Novel non-β-lactam inhibitor of β-lactamase tem-171 based on acylated phenoxyaniline / V. G. Grigorenko, I. P. Andreeva, M. Y. Rubtsova et al. // Biochimie. — 2017. — Vol. 132. — P. 45–53. The microbial resistance to antibiotics is a genuine global threat. Consequently, a search of new inhibitors remains of acute importance due to the increasing spread of multidrug resistance. Here we present a new type of non-β-lactam β-lactamase inhibitor PA-34 based on natural phenoxyaniline, identified using computer-assisted screening of scaffolds related to those of known low-affinity inhibitors. The compound displays reversible competitive inhibition of bacterial β-lactamase TEM-171, with a Ki of 88 μM. Using enzyme kinetics, infra-red spectroscopy, fluorescence quenching and computer docking, we propose that the inhibitor binds at the entrance to the enzyme active site. This is a novel inhibition mechanism compared to binding covalently to the catalytic serine in the active site or non-covalently to the allosteric site. The residues involved in binding the inhibitor are conserved among molecular class A β-lactamases. The identified compound and its proposed binding mode may have a potential for a regulation of the catalytic activity of a wide range of class A β-lactamases. We also hypothesise that the presented route for finding non-β-lactam compounds may be an effective and durable approach for combating bacterial antibiotic resistance. [ DOI ]

Photosensitizers based on bacteriochlorophyll a derivatives and silica nanoparticles: synthesis and photophysical properties / M. A. Grin, I. V. Pantiushenko, A. V. Lobanov et al. // Макрогетероциклы. — 2017. — Vol. 10, no. 3. — P. 273–278. [ DOI ]

Preparing metal-complex surfaces based on self-assembled monolayers of thiols and disulfides on gold / V. D. Dolzhikova, Y. G. Bogdanova, A. G. Majouga et al. // Russian Journal of Physical Chemistry A. — 2017. — Vol. 91, no. 2. — P. 240–246. The complexation of monolayers of sulfur-containing ligands self-assembled on gold surface with Co(II) and Cu(II) ions is studied using Quartz Crystal Microbalance (QCM) and wetting measurements. The optimum conditions for obtaining metal-complex surfaces and compositions of the resulting monolayers are determined. [ DOI ]

Regioselective hydrogenolysis of donor-acceptor cyclopropanes with zn-acoh reductive system / K. L. Ivanov, E. V. Villemson, G. V. Latyshev et al. // Journal of Organic Chemistry. — 2017. — Vol. 82, no. 18. — P. 9537–9549. [ DOI ]

Small-molecule inhibitors of hepatitis c virus (hcv) non-structural protein 5a (ns5a): a patent review (2010-2015) / Y. A. Ivanenkov, V. A. Aladinskiy, N. A. Bushkov et al. // Expert Opinion on Therapeutic Patents. — 2017. — Vol. 27, no. 4. — P. 401–414. [ DOI ]

Stop-frame filming and discovery of reactions at the single-molecule level by transmission electron microscopy / T. W. Chamberlain, J. Biskupek, S. T. Skowron et al. // ACS Nano. — 2017. — Vol. 11, no. 3. — P. 2509–2520.

Synthesis 5-(pyrazolin-3-ylmethylidene)-2-thiohydantoins and 2-alkylsulfanyl-5-(pyrazolin-3-ylmethylidene)-3,5-dihydro-4h-imidazol-4-ones / N. I. Vorozhtsov, L. A. Sviridova, O. S. Grigorkevich et al. // Russian Chemical Bulletin. — 2017. — Vol. 66, no. 3. — P. 506–510. A reaction of 3-allyl- and 3-phenylthiohydantoins with 1,5-diphenyl- and 1-phenyl-substituted 3-formyl-2-pyrazolines was used to obtain a series of 5-(pyrazolin-3-ylmethylidene)-2-thioxotetrahydro-4H-imidazol-4-ones, the subsequent alkylation of which with methyl iodide or ethyl chloroacetate gave the corresponding 2-alkylthio-5-(pyrazolin-3-ylmethylidene)-3,5-dihydro-4H-imidazol-4-ones in the yields from 30 to 77%. The oxidation of (5Z)-3-phenyl-5-[(1,5-diphenylpyrazolin-3-yl)methylidene]-2-methylsulfanyl-4,5-dihydroimidazol-4-one with lead tetraacetate led to the corresponding pyrazole in 48% yield. [ DOI ]

Synthesis and investigation of photophysical and biological properties of novel s-containing bacteriopurpurinimides / I. V. Pantushenko, P. V. Ostroverkhov, E. A. Plotnikova et al. // Journal of Medicinal Chemistry. — 2017. — Vol. 60, no. 24. — P. 10220–10230. [ DOI ]

Synthesis, sar and molecular docking study of novel non-β-lactam inhibitors of tem type β-lactamase / R. L. Antipin, D. A. Beshnova, R. А. Petrov et al. // Bioorganic and Medicinal Chemistry Letters. — 2017. — Vol. 27, no. 7. — P. 1588–1592. The novel classes of acylated phenoxyanilide and thiourea compounds were investigated for their ability to inhibit TEM type β-lactamase enzyme. Two compounds 4g and 5c reveal the inhibition potency in micromolar range and show their action by non-covalent binding in the vicinity of the TEM-171 active site. The structure activity relationship around carbon chain length and different substituents in ortho- and para-positions of acylated phenoxyanilide as well as molecular modelling study has been performed. [ DOI ]

Synthesis, characterization and mri application of magnetite water-soluble cubic nanoparticles / N. Aleksey, F. Mariia, N. Victor et al. // Journal of Magnetism and Magnetic Materials. — 2017. — Vol. 441. — P. 6–13. Magnetic nanoparticle size is one of the key factors determining its magnetic and biological properties. Herein, we report a synthesis of magnetite uniform-sized cubic nanoparticles with 10, 15 and 20 nm edge lengths for magnetic resonance imaging (MRI). The structure and physicochemical properties of obtained magnetite nanocubes (MNCbs) were studied by multiple methods. MNCbs conjugated with Pluronic F-127 exhibited high colloidal stability in aqueous medium. Synthesized MNCbs demonstrated improved T2-relaxation comparing to commercially available contrast agents proving that these nanocubes can be used for MRI. [ DOI ]

Synthesis, characterization and mri application of magnetite water-soluble cubic nanoparticles / A. Nikitin, M. Fedorova, V. Naumenko et al. // Journal of Magnetism and Magnetic Materials. — 2017. — Vol. 441. — P. 6–13.

The dynamics of magnetic nanoparticles exposed to non-heating alternating magnetic field in biochemical applications: theoretical study / Y. I. Golovin, S. L. Gribanovsky, D. Y. Golovin et al. // Journal of Nanoparticle Research. — 2017. — Vol. 19, no. 2. — P. 59. [ DOI ]

Theranostic multimodal potential of magnetic nanoparticles actuated by non-heating low frequency magnetic field in the new-generation nanomedicine / Y. I. Golovin, N. L. Klyachko, A. G. Majouga et al. // Journal of Nanoparticle Research. — 2017. — Vol. 19, no. 2. — P. 63. [ DOI ]

БИОЛОГИЧЕСКОЕ ИССЛЕДОВАНИЕ ПРОДУКТОВ МЕДЬКАТАЛИЗИРУЕМОГО s-АРИЛИРОВАНИЯ 5-АРИЛИДЕН-2-ТИОКСОИМИДАЗОЛИН-4-ОНОВ / Г. М. Аверочкин, Е. А. Длин, А. В. Финько и др. // Российский биотерапевтический журнал. — 2017. — Т. 16. — С. 3–4.

БИЯДЕРНЫЕ КООРДИНАЦИОННЫЕ СОЕДИНЕНИЯ МЕДИ (ii), (i) НА ОСНОВЕ 2-ТИОКСО-ТЕТРАГИДРО-4Н-ИМИДАЗОЛ-4-ОНА: МОДИФИКАЦИЯ ДЛЯ СТАБИЛИЗАЦИИ cu (i) В ФИЗИОЛОГИЧЕСКИХ ЖИДКОСТЯХ / Д. А. Гук, В. М. Малинников, О. О. Красновская и др. // Российский биотерапевтический журнал. — 2017. — Т. 16. — С. 48–49.

ГДЕ РОЖДАЮТСЯ ИННОВАЦИИ: РАЗРАБОТКИ МЕНДЕЛЕЕВСКОГО УНИВЕРСИТЕТА ДЛЯ ТЕХНОЛОГИЧЕСКОГО РАЗВИТИЯ РОССИИ / А. Г. Мажуга, Т. Г. Гусева, М. А. Сиротина и др. // Вестник химической промышленности. — 2017. — С. 52–53.

ДОКЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ НА ОСНОВЕ ОРГАНИЧЕСКОГО ДИСПИРОПРОИЗВОДНОГО ДЛЯ ТЕРАПИИ КОЛОРЕКТАЛЬНОГО РАКА / А. А. Белоглазкина, Г. А. Котовский, А. А. Барашкин и др. // Российский биотерапевтический журнал. — 2017. — Т. 16. — С. 10–10.

ИССЛЕДОВАНИЕ in vivo ПОТЕНЦИАЛЬНОГО ПРОТИВООПУХОЛЕВОГО ПРЕПАРАТА НА ОСНОВЕ СПИРОИНДОЛИНОНОВОГО ФРАГМЕНТА / М. Е. Кукушкин, Е. К. Белоглазкина, Н. В. Зык и др. // Российский биотерапевтический журнал. — 2017. — № 16. — С. 47–47.

Получение металлокомплексных поверхностей на основе монослоев тиолов и дисульфидов, самоорганизующихся на поверхности золота / В. Д. Должикова, Ю. Г. Богданова, А. Г. Мажуга и др. // Журнал физической химии. — 2017. — Т. 91, № 2. — С. 241–246. Методами смачивания и пьезокварцевого микровзвешивания исследовано комплексообразлвание монослоев серосодержащих лигандов, самоорганизующихся на поверхности золота, с ионами переходных металлов. Определены оптимальные условия получения металлокомплексных поверхностей и определен состав образующегося монослоя. [ DOI ]

РАЗДЕЛЕНИЕ ФАРМАКОЛОГИЧЕСКИ АКТИВНЫХ АЗОТСОДЕРЖАЩИХ СОЕДИНЕНИЙ НА СИЛИКАГЕЛЯХ, МОДИФИЦИРОВАННЫХ 6,10-ИОНЕНОМ, СУЛЬФАТОМ ДЕКСТРАНА И НАНОЧАСТИЦАМИ ЗОЛОТА ЖУРНАЛ ФИЗИЧЕСКОЙ ХИМИИ / А. Н. Иоутси, Е. Н. Шаповалова, В. А. Иоутси и др. // Журнал физической химии. — 2017. — Т. 91, № 12. — С. 2115–2121. Исследованы новые стационарные фазы для ВЭЖХ, полученные методом послойного нанесения полиэлектролитов: силикагель, послойно модифицированный 6,10-ионеном и сульфатом декстра- на (Сорбент-1), силикагель, модифицированный таким образом дважды (Сорбент-2), а также сили- кагель, модифицированный 6,10-ионеном, наночастицами золота и сульфатом декстрана (Сор- бент-3). Исследовано влияние содержания органического растворителя в подвижной фазе, а также концентрации и рН буферного раствора на хроматографическое поведение ряда фармакологически активных азотсодержащих соединений. Установлено, что сорбенты стабильны в работе и позволя- ют эффективно разделять бета-блокаторы, блокаторы кальциевых каналов, альфа-агонисты и анти- гистаминные препараты. На силикагеле, модифицированном 6,10-ионеном, наночастицами золота и сульфатом декстрана, смесь кофеина, надолола, тетрагидрозолина, пиндолола, орфенадрина, доксиламина, карбиноксамина и хлорфенирамина разделена за 6.5 мин. DOI: 10.7868/S0044453717120111. [ DOI ]

РАЗРАБОТКА ПОТЕНЦИАЛЬНЫХ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВ — ИНГИБИТОРОВ БЕЛОК-БЕЛКОВОГО ВЗАИМОДЕЙСТВИЯ p53-mdm2 НА ОСНОВЕ ДИСПИРОИНДОЛИНОНОВ / А. А. Белоглазкина, Г. А. Котовский, М. А. Кунин и др. // Российский биотерапевтический журнал. — 2017. — Т. 16, № S1. — С. 8–9.

РАЗРАБОТКА ПОТЕНЦИАЛЬНЫХ ПРОТИВООПУХОЛЕВЫХ ПРЕПАРАТОВ — ИНГИБИТОРОВ БЕЛОК-БЕЛКОВОГО ВЗАИМОДЕЙСТВИЯ p53-mdm2 НА ОСНОВЕ ДИСПИРОИНДОЛИНОНОВ / А. А. Барашкин, А. А. Белоглазкина, Г. А. Котовский и др. // Российский биотерапевтический журнал. — 2017. — Т. 16, № S1. — С. 8–9.

СИНТЕЗ И БИОЛОГИЧЕСКИЕ ИСПЫТАНИЯ КОНЪЮГАТОВ ПАКЛИТАКСЕЛА ДЛЯ ТЕРАПИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ / А. П. Бер, А. Э. Мачулкин, Н. С. Воробьева и др. // Российский биотерапевтический журнал. — 2017. — Т. 16, № Спецвыпуск. — С. 10–11.

СИНТЕЗ И БИОЛОГИЧЕСКИЕ ИСПЫТАНИЯ КОНЪЮГАТОВ ПАКЛИТАКСЕЛА ДЛЯ ТЕРАПИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ / А. П. Бер, А. Э. Мачулкин, Н. С. Воробьева и др. // Российский биотерапевтический журнал. — 2017. — Т. 16. — С. 10–11.

СИНТЕЗ КОНЪЮГАТОВ ЛИГАНДОВ ПРОСТАТИЧЕСКОГО СПЕЦИФИЧЕСКОГО МЕМБРАННОГО АНТИГЕНА С ДОКСОРУБИЦИНОМ ДЛЯ ТЕРАПИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ И ИХ БИОЛОГИЧЕСКОЕ ТЕСТИРОВАНИЕ / А. Э. Мачулкин, А. С. Гаранина, И. И. Киреев и др. // Российский биотерапевтический журнал. — 2017. — Т. 16, № Спецвыпуск. — С. 51–51.

Синтез 5-(пиразолин-3-илметилиден)-2-тиогидантоинов и 2-алкилсульфанил-5- (пиразолин-3-илметилиден)-3,5-дигидро-4Н-имидазол-4-онов / Н. И. Ворожцов, Л. А. Свиридова, О. С. Григоркевич и др. // Известия Академии наук. Серия химическая. — 2017. — № 3. — С. 506–510.

ЭКСПЕРИМЕНТАЛЬНЫЕ НАПРАВЛЕНИЯ В РАЗРАБОТКЕ СРЕДСТВ НАПРАВЛЕННОЙ ДОСТАВКИ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ В КЛЕТКИ ПЕЧЕНИ / Я. А. Иваненков, С. Ю. Маклакова, Е. К. Белоглазкина и др. // Успехи химии. — 2017. — Т. 86, № 8. — С. 750–776. [ DOI ]

A comprehensive insight into the chemical space and adme features of small molecule ns5a inhibitors / Y. Ivanenkov, M. Veselov, A. Shakhbazyan et al. // Current Topics in Medicinal Chemistry. — 2016. — Vol. 16, no. 12. — P. 1372–1382.

An improved protocol for synthesis of 3-substituted 5-arylidene-2-thiohydantoins: Two-step procedure alternative to classical methods / O. Y. Kuznetsova, R. L. Antipin, A. V. Udina et al. // Journal of Heterocyclic Chemistry. — 2016. — Vol. 53, no. 5. — P. 1570–1577. [ DOI ]

Computational insight into the chemical space of plant growth regulators / Н. А. Бушков, М. С. Веселов, Р. ЧУПРОВ-НЕТОЧИН et al. // Phytochemistry. — 2016. — Vol. 122. — P. 254–264.

Conformations, vibrational spectra and force field of 1-methyl-2-(2′-pyridyl)benzimidazole: experimental data and density functional theory investigation in comparison with 2-(2′-pyridyl)benzimidazole / G. M. Kuramshina, O. A. Vakula, N. I. Vakula et al. // Structural Chemistry. — 2016. — Vol. 27, no. 1. — P. 209–219. Jerzy Leszczynski. [ DOI ]

Copper-containing enzymes: Site types and low-molecular-weight model compounds / K. I. Tishchenko, E. K. Beloglazkina, A. G. Mazhuga, N. V. Zyk // Review Journal of Chemistry. — 2016. — Vol. 6, no. 1. — P. 49–82. [ DOI ]

Identification of novel small-molecule asgp-r ligands / A. G. Majouga, Y. A. Ivanenkov, M. S. Veselov et al. // Current Drug Delivery. — 2016. — Vol. 13, no. 8. — P. 1303–1312. [ DOI ]

In silico approaches to the design of ns5a inhibitors /  Ivanenkov, Y. A. Veselov, M. S. Aladinskiy et al. // Current Topics in Medicinal Chemistry. — 2016. — Vol. 16, no. 12. — P. 1383–1391.

Investigation of the interactions and bonding between carbon and group viii metals at the atomic scale / Z. Thilo, T. W. Chamberlain, B. Johannes et al. // Small. — 2016. — Vol. 12, no. 12. — P. 1649–1657. The nature and dynamics of bonding between Fe, Ru, Os, and single-walled carbon nanotubes (SWNTs) is studied by aberration-corrected high-resolution transmission electron microscopy (AC-HRTEM). The metals catalyze a wide variety of different transformations ranging from ejection of carbon atoms from the nanotube sidewall to the formation of hollow carbon shells or metal carbide within the SWNT, depending on the nature of the metal. The electron beam of AC-HRTEM serves the dual purpose of providing energy to the specimen and simultaneously enabling imaging of chemical transformations. Careful control of the electron beam parameters, energy, flux, and dose allowed direct comparison between the metals, demonstrating that their chemical reactions with SWNTs are determined by a balance between the cohesive energy of the metal particles and the strength of the metal–carbon σ- or π-bonds. The pathways of transformations of a given metal can be drastically changed by applying different electron energies (80, 40, or 20 keV), thus demonstrating AC-HRTEM as a new tool to direct and study chemical reactions. The understanding of interactions and bonding between SWNT and metals revealed by AC-HRTEM at the atomic level has important implications for nanotube-based electronic devices and catalysis. [ DOI ]

Magnetocontrollability of fe7c3@c superparamagnetic nanoparticles in living cells / A. Irina, K. Igor, G. Anastasia et al. // Journal of Nanobiotechnology. — 2016. — Vol. 14. — P. 67. [ DOI ]

Model of controlled drug release from functionalized magnetic nanoparticles by a nonheating alternating-current magnetic field / Y. I. Golovin, N. L. Klyachko, S. L. Gribanovskii et al. // Technical Physics Letters. — 2016. — Vol. 42, no. 3. — P. 267–270. A magnetohydrodynamic model of controlled drug macromolecule release from transport magnetic nanoparticles covered by a polymer shell under the influence of a low-frequency (<1 kHz) nonheating magnetic field is described. [ DOI ]

Nanohybride materials based on magnetite-gold nanoparticles for diagnostics of prostate cancer: Synthesis and in vitro testing / A. E. Machulkin, A. S. Garanina, O. A. Zhironkina et al. // Bulletin of Experimental Biology and Medicine. — 2016. — Vol. 161, no. 5. — P. 706–710. [ DOI ]

Nanozyme technology at moscow state university. achievements and development perspectives / E. A. Zaitseva, Y. I. Golovin, O. A. Kost et al. // Moscow University Chemistry Bulletin. — 2016. — Vol. 71, no. 4. — P. 209–220. The work describes novel functional bionanosystems for treatment and diagnostics on the basis of proteins, enzymes, polymeric coatings, and magnetic nanoparticles developed at Lomonosov Moscow State University Laboratory for Chemical Design of Bionanomaterials in collaboration with scientists from UNC Eshelman School of Pharmacy (USA). The properties of enzymes (superoxide dismutase, catalase, organophosphate hydrolase, and lysines of bacteriophages) and other drug molecules immobilized in polymeric complexes, as well as the methods for targeted drug delivery using cell-mediated systems and magnetic nanoparticles in in vitro and in vivo operating conditions, are discussed. Physical and chemical characteristics, including data on the functional properties of the nanoformulations, are obtained. The nanoformulations developed demonstrated high potential therapeutic efficacy for the treatment of central nervous system and brain diseases, inflammations (including inflammatory diseases of the eye), cancer and infectious diseases, neurotoxic injury, and others. The possibilities of remote control biochemical reactions using a nonheating low-frequency alternating magnetic field (AMF) for the controlled release of drugs are analyzed in the review. The experimental results of the AMF effects on bionanosystems containing magnetic nanoparticles, such as changing the catalytic activities of enzymes bound to magnetic nanoparticles and ‘disordering’ of the lipid bilayer in membranes, are considered. Keywords: nanomedicine, enzymes, block copolymers, nanozymes, targeted drug delivery, theranostics, functionalized magnetic nanoparticles, low-frequency alternating magnetic field, controlled release of drugs. [ DOI ]

Non-dopamine receptor ligands for the treatment of parkinson's disease. insight into the related chemical/property space / Y. A. Ivanenkov, M. S. Veselov, A. G. Majouga et al. // Molecular Diversity. — 2016. — Vol. 20, no. 1. — P. 345–365.

Novel photosensitizer based on bacteriopurpurinimide and magnetite nanoparticles / N. V. Suvorov, M. A. Grin, A. M. Popkov et al. // Макрогетероциклы. — 2016. — Vol. 9, no. 2. — P. 175–179.

Reaction of arylboronic acids with 5-aryl-3-substituted-2-thioxoimidazolin-4-ones / E. A. Dlin, G. M. Averochkin, A. V. Finko et al. // Tetrahedron Letters. — 2016. — Vol. 57, no. 49. — P. 5501–5504. [ DOI ]

Separation of water soluble vitamins on silica modified with l cysteine–stabilized gold nanoparticles using hplc / Y. A. Polyakova, I. A. Anan'eva, E. N. Shapovalova et al. // Moscow University Chemistry Bulletin. — 2016. — Vol. 71, no. 1. — P. 54–59. Silica functionalized with 3 aminopropyltriethoxysilane and L cysteine–stabilized gold nano particles has been obtained (SiO2–NH2–Au–L cysteine). The influence of pH and the content of acetoni trile in the mobile phase on retention and separation selectivity of eight vitamins has been studied. The chro matographic conditions that enable the separation of C, B3, B12, B5 and B1, B2, B6, B10 mixtures of vita mins have been proposed. It has been found that it is possible to separate a mixture of vitamins C, B3, B12, and B5 in 8 minutes, and a mixture of vitamins B1, B2, B6, B10 in 12 min on the synthesized sorbent SiO2– NH2–Au–L cysteine in isocratic elution mode. [ DOI ]

Small-molecule psma ligands. current state, sar and perspectives / A. E. Machulkin, Y. A. Ivanenkov, A. V. Aladinskaya et al. // Journal of Drug Targeting. — 2016. — Vol. 24, no. 8. — P. 679–693. [ DOI ]

Synthesis and biological testing of (5z)-2-aryl-5-arylmethylidene-3,5-dihydro-4h-imidazol-4-ones as antimitotic agents / A. A. Beloglazkina, W. Birgit, E. S. Barskaia et al. // Medicinal Chemistry Research. — 2016. — Vol. 25, no. 6. — P. 1239–1249. Compounds interacting with cell protein tubulin and microtubules represent an important type of antimitotic agents. A series of tubulin-targeted 2-aryl-4-benzoyl-imidazoles were reported to possess high cytotoxicity, and so, we prepared a series of structural isomers of these to be evaluated as antimitotic agents. The synthesis of the novel (Z)-2-aryl-5-arylmethylidene-3,5-dihydro-4H-imidazol-4-ones involved coupling of substituted hippuric acids with aromatic aldehydes. Subsequent conversion of the resulting oxazolones to the corresponding imidazolones was carried out under microwave irradiation in the presence of urea and ammonium acetate. The cytotoxicity of the majority of the compounds to human epithelial carcinoma cancer cell line A549 was in the sub-micromolar range and was found to be more sensitive to the substituents on the 5-arylmethylidene fragment than on the 2-aryl ring in general. The cytotoxicities of the synthesized compounds were lower than those of the previously reported isomeric 2-aryl-4-benzoyl-imidazoles, and the basic structure–activity relationships in the isomeric pairs were different. Synthesized (5Z)-5-[(4-bromophenyl)methylidene]-2-(4-methylphenyl)-3,5-dihydro-4H-imidazol-4-one, which had the highest cytotoxicity (IC50 ∼ 440 nM) in the series of novel compounds, had a definite cytostatic effect on the A549 cells, but its antiproliferative properties were not linked to action on the microtubules. This would be an interesting lead compound for additional investigation into the mechanism of cytostatic action, and further structural optimization. [ DOI ]

Synthesis of (5z,5´z)3,3´(alkan-α,ω-diyl)bis[5-(2-pyridylmethylene)-2-methylthuio-3,5-dihydro-4Н-imidazol-4-ones]-and their coordination compounds with copper(ii) / K. I. Tischenko, E. K. Beloglazkina, M. A. Proskurnin и др. // Russian Chemical Bulletin. — 2016. — Т. 65, № 5. — С. 1254–1259.

Synthesis, characterization, cytotoxicity and antibacterial activity of ruthenium(ii) and rhodium(iii) complexes with sulphur-containing terpyridines / E. K. Beloglazkina, E. A. Manzheliy, A. A. Moiseeva et al. // Polyhedron. — 2016. — Vol. 107. — P. 27–37. The synthesis and characterization of novel thioacetyl-functionalised terpyridine ligands and their ruthenium and rhodium complexes [Ru(tpy)2](PF6)2, [Rh(tpy)2](PF6)3, [Ru(phen)(tpy)Cl](PF6), [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = S-[ω-(2,2:6’,2’’-terpyridin-4’-yl)phenoxy]alkyl ethanethioate) have been described. Ligands and complexes were characterized by 1H NMR spectroscopy, mass spectrometry, elemental analysis and cyclic voltammetry data. The crystal structure of the complex [Rh(phen)(tpy)Cl](PF6)2 (phen = phenanthroline; tpy = 4’-phenyl-2,2’:6’,2’’–terpyridine) (21), have been determined by X-ray crystallography. Complex 21 show a distorted octahedral geometry around the ruthenium centre. Antimicrobial activity toward E. coli at concentrations as low as 5 μM was found for some of the studied complexes. For complexes [Rh(tpy-C6H4-O(CH2)8-SCOCH3)2](PF6)3 (19), [Rh(phen)(tpy-C6H4-O-(CH2)8-SCOCH3)Cl](PF6)2 (31) and [Rh(phen)(tpy-C6H4-O-(CH2)11-SCOCH3)Cl](PF6)2 (32), a strong inhibition of in vitro protein synthesis was observed using firefly luciferase. An investigation of cytotoxicity of the complexes against human embryonic kidney cells (HEK293 line) by the MTT assay demonstrates that the toxicity of all tested compounds is of similar magnitude, with IC50 values of 3 to 30 μM. [ DOI ]

Synthesis, isomerization and biological activity of novel 2-selenohydantoin derivatives / Y. A. Ivanenkov, M. S. Veselov, I. G. Rezekin et al. // Bioorganic and Medicinal Chemistry. — 2016. — Vol. 24, no. 4. — P. 802–811. A set of novel selenohydantoins were synthesized via a convenient and versatile approach involving the reaction of isoselenocyanates with various amines. We also revealed an unexpected Z→E isomerization of pyridin-2-yl-substituted selenohydantoins in the presence of Cu2+ cations. The detailed mechanism of this transformation was suggested on the basis of quantum-chemical calculations, and the key role of Cu2+ was elucidated. The obtained compounds were subsequently evaluated against a panel of different cancer cell lines. As a result, several molecules were identified as promising micromolar hits with good selectivity index. Instead of analogous thiohydantoins, which have been synthesized previously, selenohydantoins demonstrated a relatively high antioxidant activity comparable (or greater) to the reference molecule, Ebselen, a clinically approved drug candidate. The most active compounds have been selected for further biological trials. [ DOI ]

The first example of cu(i) complex with 5-pyrazolyl-2-thioxotetrahydro-4h-imidazol-4-one: synthesis and structural characterization inorganic chemistry / E. K. Beloglazkina, N. I. Vorozhtsov, L. A. Sviridova et al. // Inorganic Chemistry Communications. — 2016. — Vol. 71. — P. 86–89. A new organic ligand 3-phenyl-5-((Z)-1,5-diphenyl-pyrazol-3- yl)methylene)-2-methylthio-4,5-dihydro-imidazol-4-one (L) has been synthesized by a two step reaction sequence starting from 3-phenyl-2- thiohydantoin and 3-formyl-pyrazoline. The complex of copper(I) with L2СuClO4 composition was obtained by the reactions of this ligand with Сu(ClO4)2.6H2O; thus, the reduction of copper(II) took place during the complex formation. The crystal structure of synthesized complex has been determined by X-ray analysis. Copper atom has a distored tetrahedral ligand environment and coordinated by four nitrogen atoms of two ligand moieties; perchlorate ion does not participate in the coordination of the metal ion. This complex undergo reversible electrochemical reduction at -0.32 V. [ DOI ]

Дизайн и синтез лигандов asgp-рецептора на основе производных n-ацетил-галактозы / Р. А. Петров, А. Г. Мажуга, Е. К. Белоглазкина и др. // Российский биотерапевтический журнал. — 2016. — Т. 15, № 1. — С. 86–86.

Имидазол-4-оны и их диспиропроизводные - новый класс потенциальных противоопухолевых препаратов / А. А. Белоглазкина, А. А. Барашкин, А. Г. Мажуга и др. // Российский биотерапевтический журнал. — 2016. — Т. 15, № 1. — С. 10–11.

Модель контролируемого высвобождения лекарств из функциональных магнитных наночастиц негреющим переменным магнитным полем / Ю. И. Головин, Н. Л. Клячко, С. Л. Грибановский и др. // Письма в "Журнал технической физики". — 2016. — № 5. — С. 89.

НИЗКОМОЛЕКУЛЯРНЫЕ ГЛИКОКОНЪЮГАТЫ ПРОТИВОВИРУСНОГО ПРЕПАРАТА РИБАВИРИН С ПРОИЗВОДНЫМИ ГАЛАКТОЗАМИНА — НОВЫЙ ПОДХОД АДРЕСНОЙ ТЕРАПИИ ЗАБОЛЕВАНИЙ ПЕЧЕНИ / Э. Ю. Ямансаров, Р. А. Петров, С. А. Петров и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2016. — Т. 16. — С. 86–86.

НОВЫЕ КОНЪЮГАТЫ ЛИГАНДОВ asgp-РЕЦЕПТОРА С ПРОТИВООПУХОЛЕВЫМИ ПРЕПАРАТАМИ: СИНТЕЗ И БИОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ / Р. А. Петров, С. А. Петров, Э. Ю. Ямансаров и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2016. — Т. 16. — С. 62–62.

Наногибридные материалы на основе наночастиц магнетит-золото для диагностики рака предстательной железы: получение и in vitro исследование / А. Э. Мачулкин, А. С. Гаранина, О. А. Жиронкина и др. // Бюллетень экспериментальной биологии и медицины. — 2016. — Т. 161, № 5. — С. 651–655.

Наномеханика: адресная доставка лекарств / М. В. Ефремова, А. Г. Мажуга, Ю. И. Головин, Н. Л. Клячко // Природа. — 2016. — № 7. — С. 3–11.

РАЗДЕЛЕНИЕ ВОДОРАСТВОРИМЫХ ВИТАМИНОВ МЕТОДОМ ВЭЖХ НА СИЛИКАГЕЛЕ, МОДИФИЦИРОВАННОМ НАНОЧАСТИЦАМИ ЗОЛОТА, СТАБИЛИЗИРОВАННЫМИ l-ЦИСТЕИНОМ / Я. А. Полякова, И. А. Ананьева, Е. Н. Шаповалова и др. // Вестник Московского университета. Серия 2: Химия. — 2016. — Т. 57, № 1. — С. 24–30. Изучено влияние рН подвижной фазы на удерживание и селективность разделения 8 витаминов на силикагеле, модифицированном наночастицами золота, стабилизированными L-цистеином. Предложены хроматографические условия, позволяющие разделить смеси витаминов С, В3, В12, В5 и В1, В2, В6, В10. Установлено, что на синтезированном сорбенте SiO2-NH2-Au-L-цистеин можно проводить разделение смесей витаминов С, В3, В12, В5 в изократическом режиме элюирования за 8 мин и смеси витаминов В1, В2, В6, В10 за 12 мин.

Сore–shell magnetite–gold nanoparticles: Preparing and functionalization by chymotrypsin / P. G. Rudakovskaya, D. N. Lebedev, M. V. Efremova и др. // Nanotechnologies in Russia. — 2016. — Т. 11, № 3. — С. 144–152. [ DOI ]

СИНТЕЗ КОНЪЮГАТОВ – ИНГИБИТОРОВ ПРОСТАТИЧЕСКОГО СПЕЦИФИЧЕСКОГО МЕМБРАННОГО АНТИГЕНА С ДОКСОРУБИЦИНОМ ДЛЯ ТЕРАПИИ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫ / А. Э. Мачулкин, А. С. Гаранина, И. И. Киреев и др. // Российский биотерапевтический журнал. — 2016. — Т. 15, № 1. — С. 64–64.

Синтез и биологические испытания конъюгатов паклитаксела для терапии рака предстательной железы / А. П. Бер, А. Э. Мачулкин, Н. С. Воробьева и др. // Успехи молекулярной онкологии. — 2016. — Т. 3, № 4. — С. 75–75.

Синтез лигандов асиалогликопротеинового рецептора для направленной доставки биологически активных веществ в клетки печени / С. Ю. Маклакова, В. В. Гопко, Г. А. Шипулин и др. // Российский биотерапевтический журнал (Russian Journal of Biotherapy),. — 2016. — Т. 1, № 15. — С. 59–59.

Белоглазкина Е. К., Мажуга А. Г., Зык Н. В. Создание потенциальных противоопухолевых препаратов на основе диспиропроизводных 2-тиоксо-тетрагидро-4Н-имидазол-4-онов // Российский биотерапевтический журнал. — 2016. — Т. 15, № 1. — С. 55–55.

Создание потенциальных противоопухолевых препаратов на основе диспиропроизводных 2-тиоксо-тетрагидро-4Н-имидазол-4-онов / М. Е. Кукушкин, А. Г. Мажуга, Е. К. Белоглазкина, Н. В. Зык // Российский биотерапевтический журнал. — 2016. — Т. 15, № 1. — С. 55.

ТЕХНОЛОГИЯ nanozyme В МОСКОВСКОМ УНИВЕРСИТЕТЕ. ДОСТИЖЕНИЯ И ПЕРСПЕКТИВЫ РАЗВИТИЯ / Е. А. Зайцева, Ю. И. Головин, О. А. Кост и др. // Вестник Московского университета. Серия 2: Химия. — 2016. — Т. 57, № 4. — С. 211–226. Представлены новые функциональные бионаносистемы для диагностики и терапии на основе белков, ферментов, полимерных покрытий, магнитных наночастиц (МНЧ), разработанные в лаборатории Химический дизайн бионаноматериалов (кафедра химической энзимологии химического факультета МГУ) в сотрудничестве с учеными Школы фармацевтики им. Эшельмана Университета Северной Каролины (США). Обсуждаются свойства ферментов супероксиддисмутазы, каталазы, органофосфатгидролазы, лизинов бактериофагов и других лекарственных молекул в составе полимерных нанокомплексов, физико-химические характеристики полученных наноформуляций, особенности функционирования в условиях in vitro и in vivo, способы адресной доставки, в том числе с использованием клеточно-опосредованных систем и магнитных наночастиц. Показана высокая потенциальная терапевтическая эффективность разработанных нанокомпозиций для лечения болезней центральной нервной системы и головного мозга, воспалений, в том числе воспалений глаз, онкологических и инфекционные заболеваний, нейротоксических поражений и др. Анализируются возможности дистанционного управления биохимическими реакциями с помощью низкочастотного переменного магнитного поля (ПМП) для контролируемого высвобождения лекарств. Представлены и обсуждаются экспериментальные результаты по воздействию ПМП на бионаносистемы, содержащие магнитные наночастицы (изменение каталитической активности ферментов, прикрепленных к МНЧ, разрыхление билипидных мембран и др.).

A new approach to the synthesis of ligands of asialoglycoprotein receptor for targeted delivery of oligonucleotides to hepatocytes / С. Ю. Маклакова, Ф. А. Кучеров, Р. А. Петров et al. // Russian Chemical Bulletin. — 2015. — Vol. 64, no. 7. — P. 1655–1662. [ DOI ]

Alternative low frequency magnetic field theranostics: recent advances, safety and hazards / Y. Golovin, N. Klyachko, A. Majouga et al. // IOP Conference Series: Materials Science and Engineering. — 2015. — Vol. 98. — P. 12016–12024 (9). Короткий обзор и сравнительный анализ низкочастотных и радиочастотных электромагнитных полей в наномедицине. [ DOI ]

Core–shell–corona doxorubicin-loaded superparamagnetic fe3o4 nanoparticles for cancer theranostics / A. Semkina, M. Abakumov, N. Grinenko et al. // Colloids and Surfaces B: Biointerfaces. — 2015. — Vol. 136. — P. 1073–1080. Superparamagnetic iron oxide magnetic nanoparticles (MNPs) are successfully used as contrast agents in magnetic-resonance imaging. They can be easily functionalized for drug delivery functions, demonstrating great potential for both imaging and therapeutic applications. Here we developed new pH-responsive theranostic core–shell–corona nanoparticles consisting of superparamagentic Fe3O4 core that displays high T2 relaxivity, bovine serum albumin (BSA) shell that binds anticancer drug, doxorubicin (Dox) and poly(ethylene glycol) (PEG) corona that increases stability and biocompatibility. The nanoparticles were produced by adsorption of the BSA shell onto the Fe3O4 core followed by crosslinking of the protein layer and subsequent grafting of the PEG corona using monoamino-terminated PEG via carbodiimide chemistry. The hydrodynamic diameter, zeta-potential, composition and T2 relaxivity of the resulting nanoparticles were characterized using transmission electron microscopy, dynamic light scattering, thermogravimetric analysis and T2-relaxometry. Nanoparticles were shown to absorb Dox molecules, possibly through a combination of electrostatic and hydrophobic interactions. The loading capacity (LC) of the nanoparticles was 8 wt.%. The Dox loaded nanoparticles release the drug at a higher rate at pH 5.5 compared to pH 7.4 and display similar cytotoxicity against C6 and HEK293 cells as the free Dox. [ DOI ]

Design, synthesis and biological evaluation of novel potent mdm2/p53 small-molecule inhibitors / Y. A. Ivanenkov, S. V. Vasilevski, E. K. Beloglazkina et al. // Bioorganic and Medicinal Chemistry Letters. — 2015. — Vol. 25, no. 2. — P. 404–409. Abstract Regioselective synthesis, biological evaluation and 3D-molecular modeling for a series of novel diastereomeric 2-thioxo-5H-dispiro[imidazolidine-4,3-pyrrolidine-2,3-indole]-2,5(1H)-diones are described. The studied compounds have been tentatively identified as potent small molecule MDM2/p53 PPI inhibitors and can therefore be reasonably regarded as promising anticancer therapeutics. [ DOI ]

Development of bacteriochlorophyll a-based near-infrared photosensitizers conjugated to gold nanoparticles for photodynamic therapy of cancer / И. В. Пантюшенко, П. Г. Рудаковская, А. В. Старовойтова et al. // Biochemistry (Moscow). — 2015. — Vol. 80, no. 6. — P. 752–762.

Direct reagentless detection of the affinity binding of recombinanthis-tagged firefly luciferase with a nickel-modified gold electrode / M. Y. Vagin, S. A. Trashin, E. K. Beloglazkina, A. G. Majouga // Mendeleev Communications. — 2015. — Vol. 25. — P. 290–292.

Effects of cadmium chloride on the functional state of human intestinal cells / A. L. Rusanov, A. V. Smirnova, A. A. Poromov et al. // Toxicology in Vitro. — 2015. — Vol. 29, no. 5. — P. 1006–1011. Toxic effects of cadmium chloride in concentration range from 1 to 300 μM on differentiated human intestinal epithelial Caco-2 cells after three hours of exposure were investigated. Processes of disorganization of the actin cytoskeleton associated with the toxic effects of cadmium were characterized by fluorescent microscopy. The cadmium-induced activation of cellular stress response processes (changes in the mRNA expression of caspase-3, heat-shock and oxidative stress genes) has been demonstrated. The study revealed dose-dependent changes in mRNA expression levels of proteins involved in the formation of adherens (E-Cadherin and p120 catenin) and tight intercellular junction contacts (Claudin 4 and ZO1). The time- and concentration-dependent trend of cell monolayer transepithelial resistance lowering, characterizing the loss of intercellular contacts density with prolongation of cell exposure cadmium chloride was estimated. Results indicates that proteins associated with tight and adhesion junctions are primary targets of cadmium. Amongst genes involved in cell junction formation, the genes encoding E-Cadherin and p120-catenin proved to be the most sensitive to cadmium influence. [ DOI ]

Enzyme-functionalized gold-coated magnetite nanoparticles as novel hybrid nanomaterials: Synthesis, purification and control of enzyme function by low-frequency magnetic field / M. Alexander, S.-P. Marina, K. Artem et al. // Colloids and Surfaces B: Biointerfaces. — 2015. — Vol. 125. — P. 104–109. [ DOI ]

Mononuclear ruthenium(ii) and rhodium(iii) complexes with s-[4-(2,2:6’,2’’-terpyridin-4’-yl)phenoxy]butyl ethanethioate and 4’-[4-(1,2-dithiolane-3-yl)butylcarboxy)phenyl]-2,2’:6’,2’’-terpyridine / E. K. Beloglazkina, A. G. Majouga, E. A. Manzheliy et al. // Polyhedron. — 2015. — Vol. 85. — P. 800–808. [ DOI ]

Nanomechanical control of properties of biological membranes achieved by rodlike magnetic nanoparticles in a superlow-frequency magnetic field / Y. I. Golovin, N. L. Klyachko, S. L. Gribanovskii et al. // Technical Physics Letters. — 2015. — Vol. 41, no. 5. — P. 455–457. [ DOI ]

New type of organic/gold nanohybrid material: Preparation, properties and application in catalysis / A. G. Majouga, E. K. Beloglazkina, E. A. Manzheliy et al. // Applied Surface Science. — 2015. — Vol. 325. — P. 73–78. [ DOI ]

Oxidative dehydrogenation of 5-(pyridine-2-yl-methyl)-2-thioxo-4-imidazolidinones in complexation reaction with copper(ii) chloride / A. G. Majouga, E. K. Beloglazkina, A. V. Yudina et al. // Inorganic Chemistry Communications. — 2015. — Vol. 51, no. 1. — P. 114–117. [ DOI ]

Reactions of 2-aminothiophenol with pyridine- and imidazolecarboxaldehydes / Е. С. Барская, Е. К. Белоглазкина, А. Г. Мажуга et al. // Russian Chemical Bulletin. — 2015. — Vol. 64, no. 8. — P. 1975–1977.

Recent advances in the synthesis of fe3o4@au core/shell nanoparticles / S. V. Salihov, N. V. Sviridenkova, A. G. Savchenko et al. // Journal of Magnetism and Magnetic Materials. — 2015. — Vol. 394. — P. 173–178.

Synthesis and biotests of 2-aryl-5-arylmethylidene-substituted 1,3-oxazol-5(4h)-ones and n-methyl-3,5-dihydro-4h-imidazol-4-ones as combretastatin a-4 analogs / E. S. Barskaia, A. A. Beloglazkina, B. Wobith et al. // Russian Chemical Bulletin. — 2015. — Vol. 64, no. 7. — P. 1560–1563. A series of 2-aryl-5-arylmethylidene-1,3-oxazol-5(4H)-ones and 2-aryl-5-arylmethylidene-N-methyl-3,5-dihydro-4H-imidazol-4-ones was synthesized as structural analogs of combret- astatin A-4 (a compound possessing antitumor activity). (5Z)-5-[(4-Methoxyphenyl)methyl-idene]-3-methyl-2-(4-methylphenyl)-3,5-dihydro-4H-imidazol-4-one was found to exhibit the highest cytotoxicity against cells of human A549 lung carcinoma line (EC50 = 6±0.8 μmol L−1). [ DOI ]

Synthesis and characterization of peg-silane functionalized iron oxide (ii, iii) nanoparticles for biomedical application /  Rudakovskaya, M. Polina);, O. (Metelkina et al. // Nanotechnologies in Russia. — 2015. — Vol. 10, no. 11-12. — P. 896–903.

Synthesis of magnetite–gold nanoparticleswith core–shell structure / P. G. Rudakovskaya, E. K. Beloglazkina, A. G. Majouga et al. // Moscow University Chemistry Bulletin. — 2015. — Vol. 70, no. 3. — P. 149–156. Data on the synthesis of core–shelltype nanoparticles in which the core is magnetite and the shell is gold are summarized and systematized. Various approaches to the synthesis of the magnetic core and methods for coating magnetite with a gold shell are considered. [ DOI ]

The first tris(imidazolylbenzothiazole) copper(ii) complex / E. K. Beloglazkina, E. S. Barskaya, A. G. Majouga et al. // Mendeleev Communications. — 2015. — Vol. 25. — P. 148–149.

Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields / Y. I. Golovin, S. L. Gribanovsky, D. Y. Golovin et al. // Journal of Controlled Release. — 2015. — Vol. 219. — P. 43–60.

Наномеханическое управление свойствами биологических мембран с помощью стержнеобразных магнитных наночастиц в супернизкочастотном магнитном поле / Ю. И. Головин, Н. Л. Клячко, С. Л. Грибановский и др. // Письма в "Журнал технической физики". — 2015. — Т. 41, № 9. — С. 96–102.

Разработка наноструктурировнных ИК-фотосенсибилизаторов на основе производных бактериохлорофилла а и наночастиц золота для фотодинамической терапии рака / И. В. Пантюшенко, П. Г. Рудаковская, А. В. Старовойтова и др. // Biochemistry (Moscow). — 2015. — № 6. — С. 891–903.

СИНТЕЗ НАНОЧАСТИЦ МАГНЕТИТ–ЗОЛОТО, ИМЕЮЩИХ СТРУКТУРУ ТИПА ЯДРО–ОБОЛОЧКА / П. Г. Рудаковская, Е. К. Белоглазкина, А. Г. Мажуга и др. // Вестник Московского университета. Серия 2: Химия. — 2015. — Т. 56, № 3. — С. 181–189. Обобщены и систематизированы данные по методам синтеза наночастиц типа ядро–обо- лочка, в которых ядром является магнетит, а оболочкой – золото. Рассмотрены различные подходы к синтезу магнитного ядра, а также способы покрытия магнетита оболочкой золота.

Синтез и биотестирование 2-арил-5-арилметилидензамещенных 1,3-оксазол-5(4h)-онов и n-метил-3,5-дигидро-4h-имидазол-4-онов в качестве аналогов комбретастатина А-4 / Е. С. Барская, А. А. Белоглазкина, Б. Вобит и др. // Известия Академии наук. Серия химическая. — 2015. — № 7. — С. 1560–1563.

Синтез, оптимизация методов получения наночастиц магнетита различного размера и морфологии для биологического применения / Н. В. Пулькова, С. А. Тоневицкая, В. М. Герасимов и др. // Российские нанотехнологии. — 2015. — Т. 10, № 7-8.

Computational approaches to the design of novel 5-ht6 r ligands / Y. A. Ivanenkov, A. G. Majouga, M. S. Veselov et al. // Reviews in the Neurosciences. — 2014. — Vol. 25, no. 3. — P. 451–467. [ DOI ]

Conversion of 2-thiohydantoins and their derivatives to the corresponding hydantoins in the processes of complexation reactions with copper(ii) chloride dihydrate / K. B. . Elena, A. G. Majouga, A. V. Mironov et al. // Polyhedron. — 2014. — Vol. 76. — P. 45–50. The treatment of 5-pyridylmethylene-substituted 2-thiohydantoins or 2-alkylthio-3,5-dihydro-4H-imidazole-4-ones with CuCl2*2H2O affords the mononuclear or polymeric copper(II) complexes of the corresponding hydantoins. A presumable mechanism of hydantoin moiety formation involves Lewis acid catalyzed nucleophilic substitution of a sulfur-containing leaving group in the organic ligand by a water molecule from CuCl2 . 2H2O. The copper complexes Cu(L1-H)Cl(H2O) (7; L1 = (Z)-3-allyl-5-(pyridine-2-ylmethylene)imidazole-2,4(4H)-dione) and Cu(L2-H)2 (9; L2 = Z)-3-allyl-5-(50-bromo-pyridine-2-ylmethylene) imidazole-2,4(4H)-dione) were characterized by X-ray diffraction. [ DOI ]

Copper(ii) complex with (4z,4z’)-1,1’-(disufanediylbis(ethane-2,1-diyl))bis(2-methylthio)-4-(pyridin-2-ylmethylene)-1h-imidazol-5(4h)-one) onto a gold electrode surface – a catalyst of electrochemical reduction of nitrite in water solution / E. K. Beloglazkina, O. Y. Kuznetsova, A. G. Majouga et al. // Mendeleev Communications. — 2014. — Vol. 24. — P. 37–39.

Copper(ii) complexes with 3-(2-pyridyl)-4,5-dihydro-1h-pyrazoles: synthesis, structural and electrochemical studies / Н. И. Ворожцов, А. Г. Мажуга, Е. К. Белоглазкина et al. // Russian Chemical Bulletin. — 2014. — no. №3. — P. 657–661. Три новых координационных соединения меди(II) с лигандами ряда 3#(2#пиридил)#4,5# дигидро#1H#пиразолов получены взаимодействием соответствующих органических лиган# дов с CuCl2•2H2O. Структура комплексов установлена методом РСА. Все координацион# ные соединения имеют состав 2(L•MCl2) (L — органический лиганд); каждый ион меди имеет искаженную тригонально#бипирамидальную геометрию координационного окруже# ния и координирован двумя атомами азота (пиразолинового и пиридинового циклов), двумя мостиковыми и одним аксиальным хлорид#анионами. На основании данных метода ЦВА предложена последовательность стадий электрооокисления и электровосстановления 3#(2#пиридил)#1,5#дифенил#4,5#дигидро#1H#пиразола и его комплекса с CuII. [ DOI ]

Copper(ii) complexes with 3-(2-pyridyl)-4,5-dihydro-1h-pyrazoles: synthesis, structural and electrochemical studies / N. I. Vorozhtsov, A. G. Majouga, E. K. Beloglazkina et al. // Russian Chemical Bulletin. — 2014. — Vol. 63, no. 3. — P. 657–661.

Dietary polyphenols for prostate cancer therapy / Y. A. Ivanenkov, N. V. Chufarova, M. S. Veselov, A. G. Majouga // Current Bioactive Compounds. — 2014. — Vol. 10. — P. 77–111. This review describes the potential of a variety of physiologically active natural dietary polyphenols (PPhs) and their analogues, including derivatives of flavonoids, stilbenes, lignans, curcuminoids, and tannins, for prostate cancer chemotherapy. The large number of scientific papers on PPhs published during the last decade, particularly those focused on their therapeutic potential against prostate cancer cell lines, indicates rising interest in this group of compounds. Several polyphenolic agents are currently being investigated in advanced clinical trials as prominent cancer drug candidates while hundreds of related compounds are being evaluated in early clinical and preclinical studies. The review also covers the key mechanisms of antitumor action of natural PPhs against cancer cells.

Enzyme-functionalized gold-coated magnetite nanoparticles as novel hybrid nanomaterials: synthesis purification and control of enzyme function by low-frequency magnetic field / A. Majouga, M. Sokolsky-Papkov, A. Kuznetsov et al. // Colloids and Surfaces B: Biointerfaces. — 2014. — Vol. 125. — P. 104–109.

Mixed valence copper(i,ii) binuclear complexes with unexpected structure: Synthesis, biological properties and anticancer activity / A. G. Majouga, M. I. Zvereva, M. P. Rubtsova et al. // Journal of Medicinal Chemistry. — 2014. — Vol. 57. — P. 6252–6258. We have synthesized and characterized a panel of new binuclear mixed valence Cu(I,II)complexes containing substituted 2-alkylthio-5-arylmethylene-4H-imidazolin-4-ones with unusual structure. These complexes are shown to be cytotoxic for various cell lines. We have found that these compounds did not intercalate DNA, inhibited number of polymerases (telomerase predominantly), accumulated in the cell nucleus, and caused DNA degradation. Preliminary studies revealed that lead compound inhibited human breast adenocarcinoma growth in mice model.

New bionanosystems for medical applications. the development of " nanozyme" technology in moscow state university / N. Klyachko, E. Zaitseva, E. Efremenko et al. // Moscow University Chemistry Bulletin. — 2014. — Vol. 55, no. 3. — P. 139–147. Using NanoZYME technology, novel types of bionanosystems for phosphor organic neurotoxins decomposition, for treatment of eye inflammation and spinal cord injury treatment as well as bacterial infections fighting have been developed. Hybrid nanomaterials, containing superparamagnetic nanoparticles, organic ligands and enzymes promising for therapy and diagnostics have been obtained. A new approach to the control of biochemical reactions in a magnetic nanosuspension using a low-frequency magnetic field is presented.

Manoj S., Alexander M. The cytotoxicity and cellular stress by temperature-fabricated polyshaped gold nanoparticles using marine macroalgae, padina gymnospora // Biotechnology and Applied Biochemistry. — 2014.

Модели наномеханического управления свойствами биологических мембран с помощью стержнеобразных магнитных наночастиц в переменном магнитном поле / Ю. И. Головин, Н. Л. Клячко, С. Л. Грибановский и др. // Материалы Научно-практической конференции "Математическое моделирование в области клеточной биологии, биохимии, биофизики", 25-26 ноября. — Тольятти, 2014. — С. 101–109.

НОВЫЕ АУРОФИЛЬНЫЕ ОРГАНИЧЕСКИЕ ЛИГАНДЫ НА ОСНОВЕ 1,3-ДИБРОМПРОПАН-2-ОЛА И 2-АМИНОТИОФЕНОЛА / К. И. Тищенко, Е. К. Белоглазкина, А. Г. Мажуга и др. // Вестник Московского университета. Серия 2: Химия. — 2014. — Т. 55, № 1. — С. 29–35. Изучены реакции нуклеофильного замещения в 1,3-дибромпропан-2-оле и продуктах его ацилирования под действием 2-аминотиофенола. Показано, что образующиеся произво- дные 1,3-дитиопропан-2-ола, содержащие донорные атомы азота и серы, образуют коорди- национные соединения в реакциях с солями меди(II). Продемонстрирована возможность хемосорбции полученных лигандов и комплексов, содержащих дополнительные дисуль- фидные группировки, на поверхности золотого электрода с образованием связи Au-S.

Новые бионаносистемы для медицинских применений. Развитие технологии nanozyme в Московском государственном университете имени М.В.Ломоносова / Н. Л. Клячко, Е. А. Зайцева, Е. Н. Ефременко и др. // Вестник Московского университета. Серия 2: Химия. — 2014. — Т. 55, № 3. — С. 139 –147. C применением технологии NanoZYME разработаны новые бионаносистемы для разложения фосфорорганических нейротоксинов, для лечения воспаления глаз, травм спинного мозга и бактериальных инфекций. Получены наногибридные материалы, содержащие суперпарамагнитные наночастицы, органические лиганды и ферменты, перспективные для терапии и диагностики онкологических заболеваний. Представлен новый подход к управлению биохимическими реакциями в магнитных наносуспензиях посредством приложения низкочастотного магнитного поля.

Cleavage of the c-s bond with the formation of a binuclear copper complex with 2-thiolato-3-phenyl-5-(pyridine-2-ylmethylene)-3,5-dihydro-4h-imidazole-4-on. a new mimic of the active site of n2o reductase / A. G. Majouga, E. K. Beloglazkina, A. A. Moiseeva et al. // Dalton Transactions. — 2013. — Vol. 42, no. 18. — P. 6290–6293. The treatment of the ligands with copper(II) chloride dihydrate led to the formation of a binuclear copper complex with a [Cu+1.5Cu+1.5] redox state as a result of C–S bond cleavage in the course of the reaction. This complex catalyses the electrochemical reduction of nitrous oxide and triphenyl phosphine oxidation under N2O action. [ DOI ]

Novel copper(ii) and cobalt(ii) complexes with selenium substituted imidazolyl imines. the molecular and crystal structure of [n-(2-(phenylseleno)ethyl)-n-(imidazol-2-ylmethylene)amine]copper(ii) dichloride / E. K. Beloglazkina, A. G. Majouga, R. L. Antipin et al. // Polyhedron. — 2013. — Vol. 50, no. 13. — P. 425–433. A series of copper(II) and cobalt(II) complexes with novel selenium containing Schiff base ligands obtained from 2- or 3-aminoalkyl phenyl selenides and imidazole carbaldehydes have been synthesized by the interaction of corresponding organic ligands with MCl2·6H2O (M = Cu, Co). The crystal structure of a copper(II) complex with N-(2-(phenylseleno)ethyl)-N-(imidazolyl-2-ylmethylene)amine has been solved by a single-crystal X-ray diffraction method. The copper(II) ions are coordinated by the imine and imidazole nitrogen atoms of organic ligands and two chloride anions in a distorted square planar geometry. The electrochemical investigations of the synthesized ligands and complexes have been made by cyclic voltammetry method. It is established that the first stage of complexes reduction takes place to metal and the reduced forms of complexes are stable in the solution.

Novel ditopic organic ligands containing the terpyridine and 2-thiohydantoin fragments / Е. А. Манжелий, Е. К. Белоглазкина, А. Г. Мажуга, Н. В. Зык // Russian Chemical Bulletin. — 2013. — Vol. 62, no. 12. — P. 2631–2633.

Structure determination of bis{(4z)����1����(2����azidoethyl)���� 4����[(pyridin����2����yl)methylidene]����2����thiolatoimidazol����5(4h)����one}dicopper chloride from x����ray powder diffraction data / A. V. Mironov, . E. Antipov, E. K. Beloglazkina et al. // Russian Chemical Bulletin. — 2013. — Vol. 62, no. 3. — P. 672–677. Cинтезирован новый тридентатный органический лиганд N2S-типа — (4Z)-тиоксо-4-[(пиридин-2-ил)метилен]-1-(2-азидоэтил)имидазол-5(4H)-он (LH). В результате реакции LH и хлорида меди(II) в cмеси CH2Cl2/MeOH получено координационное соединение состава L2Cu2Cl (3). Кристаллическая структура 3 была определена и уточнена из порошковых рентгеновских данных. Комплекс 3 имеет биядерное строение с коротким межатомным расстоянием Cu—Cu и одним мостиковым атомом хлора, расположенным практически симметрично по отношению к обоим атомам металла. Плоские органические лиганды не параллельны друг другу и находятся под углом 53.56(1)o.

Synthesis, x-ray crystallography and electrochemistry of three novel copper complexes with imidazole-containing hydantoin and thiohydantoins / E. K. Beloglazkina, A. G. Majouga, A. V. Mironov et al. // Polyhedron. — 2013. — Vol. 63. — P. 15–20. [ DOI ]

Металлокомплексные поверхности на основе аурофильных терпиридинов и их координационных соединений с rh(iii) и ru(ii) / Е. К. Белоглазкина, А. Г. Мажуга, Е. А. Манжелий и др. // Бутлеровские сообщения. — 2013. — Т. 35. — С. 50–58.

Электрофоретическое разделение азотсодержащих препаратов на кварцевых капиллярах, модифицированных наночастицами золота, стабилизированных цитратом натрия, 6,10-ионенои и сульфополисахаридами / А. Н. Михалюк, Е. Н. Шаповалова, А. Г. Мажуга и др. // Вестник Московского университета. Серия 2: Химия. — 2013. — Т. 54, № 5. — С. 252–256.

Changing the enzyme reaction rate in magnetic nanosuspensions by a non-heating magnetic field / N. L. Klyachko, M. Sokolsky-Papkov, N. Pothayee et al. // Angewandte Chemie - International Edition. — 2012.

Gold nanoparticles modified with coordination compounds of metals: synthesis and application / E. K. Beloglazkina, A. G. Majouga, R. B. Romashkina et al. // Russian Chemical Reviews. — 2012. — Vol. 81, no. 1. — P. 65–90. The data on the preparation methods and applications of gold nanoparticles with coordinated metal ions on the surfaces are generalized. The currently available data on the interaction of metal ions with gold nanoparticles modified with organic (particularly, sulfur-containing) ligands comprising terminal chelating groups are considered in detail as well as the applications of such modified nanoparticles. The bibliography includes 141 references. [ DOI ]

Gold nanoparticles modified with coordination compounds of metals: synthesis and application / Е. К. Белоглазкина, А. Г. Мажуга, Р. Б. Ромашкина et al. // Russian Chemical Reviews. — 2012. — Vol. 81, no. 1. — P. 65–90.

Hplc separation of nitrogen-containing compounds on silica gel modified with gold nanoparticles stabilized by chitosan / E. N. Shapovalova, I. A. Ananieva, Y. A. Elfimova et al. // Moscow University Chemistry Bulletin. — 2012. — Vol. 67, no. 2. — P. 72–77. The potentialities of using silica gel modified with gold nanoparticles stabilized by chitosan are evaluated in the normal phase of HPLC as an example of the separation of aniline and pyridine derivatives, as well as triazole fungicides by elution with mixtures of hexane with isopropyl alcohol, isobutanol, or chloroform. The influence of the nature and content of the polar additive on the efficiency and separation selectivity of the column have been studied. The possibility of separating mixtures containing penconazole, propiconazole, diniconazole, difenoconazole, and aminopyridines is shown. [ DOI ]

New nanohybrid material based on gold nanoparticles and 1,4-bis(terpyridine-4′-yl)benzene / A. G. Mazhuga, N. V. Volkova, E. A. Manzhelii et al. // Nanotechnologies in Russia. — 2012. — Vol. 7, no. 3-4. — P. 149–151. A facile and convenient method is offered for the synthesis of composite material consisting of 1,4-bis(terpyridine-4′-yl)benzene microcrystals and gold nanoparticles with an average size of 15 nm adsorbed on their surfaces. The nanohybrid material is obtained by the deposition of presynthesized nanoparticles on the surface of the organic compound. © 2012 Pleiades Publishing, Ltd. [ DOI ]

Novel dna fluorescence probes based on 2-thioxo-tetrahydro-4h-imidazol-4-ones: synthetic and biological studies / A. G. Majouga, A. V. Udina, E. K. Beloglazkina et al. // Tetrahedron Letters. — 2012. — Vol. 53, no. 1. — P. 51–53.

Regularities of the retention of aminopyridines by silica gel modified with gold nanoparticles / Y. A. Elfimova, D. A. Pichugina, I. A. Anan’eva et al. // Russian Journal of Physical Chemistry A. — 2012. — Vol. 86, no. 10. — P. 1623–1629. [ DOI ]

Sulfur-containing terpyridine derivatives: synthesis, coordination properties, and adsorption on the gold surface / Р. Б. Ромашкина, А. Г. Мажуга, Е. К. Белоглазкина et al. // Russian Chemical Bulletin. — 2012. — Vol. 61, no. 12. — P. 2265–2281.

Synthesis and coordinating properties of 5-phenyl- and 5-pyridylmethylidene-substituted 2-selenohydantoines and 2-selenoimidazol-4-ones / М. Ю. Стеклов, А. Н. Чернышева, Р. Л. Антипин et al. // Известия Академии наук. Серия химическая. — 2012. — Vol. 61, no. 6. — P. 1182–1192. Синтезированы 2"селеноимидазолидин"4"оны и 2"селеноимидазол"4"оны, содержа" щие в положении 5 фенил" или пиридилметиленовые заместители. Структура 3"бензил" 2"селеногидантоина подтверждена методом РСА. При алкилировании 3,5"дизамещен" ных селеногидантоинов метилиодидом получена серия 2"(метилселено)имидазол"4" онов. Синтезированные селеногидантоины и 3"бензил"5"пиридилметилен"2"селеноме" тилимидазол"4"оны исследованы в реакциях комплексообразования с CoCl2, NiCl2, СuCl2, CuI(CH3CN)4ClO4; на основании данных электрохимического исследования по" казана устойчивость восстановленных форм медьсодержащих комплексов.

Закономерности удерживания аминопиридинов на силикагеле, модифицированном наночастицами золота / Я. А. Елфимова, Д. А. Пичугина, И. А. Ананьева и др. // Журнал физической химии. — 2012. — Т. 86, № 9. — С. 1–8.

Новый наногибридный материал на основе наночастиц золота и 1,4-бис(терпиридин-4'-ил) бензола / А. Г. Мажуга, Н. В. Волкова, Е. А. Манжелий и др. // Российские нанотехнологии. — 2012. — Т. 7, № 3-4. — С. 76–77.

Определение замещенных гидразинов в виде производных с 2,3-нафталиндикарбокс-альдегидом методом ВЭЖХ на силикагеле, модифицированном наночастицами золота / Я. А. Елфимова, И. А. Ананьева, А. Г. Мажуга, О. А. Шпигун // Заводская лаборатория. Диагностика материалов. — 2012. — Т. 78, № 6. — С. 20–27.

Разделение азотсодержащих соединений методом высокоэффективной жидкостной хроматографии на силикагеле, модифицированном наночастицами золота, стабилизированными хитозаном / Е. Н. Шаповалова, И. А. Ананьева, Я. А. Елфимова и др. // Вестник Московского университета. Серия 2: Химия. — 2012. — Т. 53, № 2. — С. 108–114.

Синтез и координационные свойства 5-фенил- и 5-пиридилметилензамещенных 2-селеногидантоинов и 2-селеноимидазол-4-онов / М. Ю. Стеклов, А. Н. Чернышева, Р. Л. Антипин и др. // Известия Академии наук. Серия химическая. — 2012. — № 6. — С. 1170–1180. Синтезированы 2"селеноимидазолидин"4"оны и 2"селеноимидазол"4"оны, содержа" щие в положении 5 фенил" или пиридилметиленовые заместители. Структура 3"бензил" 2"селеногидантоина подтверждена методом РСА. При алкилировании 3,5"дизамещен" ных селеногидантоинов метилиодидом получена серия 2"(метилселено)имидазол"4" онов. Синтезированные селеногидантоины и 3"бензил"5"пиридилметилен"2"селеноме" тилимидазол"4"оны исследованы в реакциях комплексообразования с CoCl2, NiCl2, СuCl2, CuI(CH3CN)4ClO4; на основании данных электрохимического исследования по" казана устойчивость восстановленных форм медьсодержащих комплексов. [ DOI ]

2-Тиоксо-тетрагидро-4Н-имидазол-4-оны, 2-алкилтио-3,5-дигидро-4Н имидазол-4-оны и их координационные соединения с ионами переходных металлов / Е. К. Белоглазкина, А. Г. Мажуга, Е. А. Манжелий и др. // Обзорный журнал по химии. — 2011. — Т. 1, № 4. — С. 299–333.

Copper (ii) coordination compounds as building blocks for the formation of gold nanoparticle dimers / R. B. Romashkina, E. K. Beloglazkina, A. N. Khlobystov et al. // Mendeleev Communications. — 2011. — Vol. 21. — P. 129–131.

Copper(ii) coordination compounds as building blocks for the formation of gold nanoparticle dimers / R. B. Romashkina, E. K. Beloglazkina, A. N. Khlobystov et al. // Mendeleev Communications. — 2011. — Vol. 21, no. 3. — P. 129–131. A new way for gold nanoparticle dimer formation based on the coordination interaction of a benzimidazole copper(II) complex with gold nanoparticles has been proposed. [ DOI ]

New organic picolylamine-type ligands and electrochemical study of their complexation with cu(mecn)(4)clo4 / A. G. Majouga, R. B. Romashkina, A. S. Kashaev et al. // Russian Chemical Bulletin. — 2011. — Vol. 60, no. 2. — P. 261–268. A series of novel organic ligands with dipicolylamine and disulfide groups connected by polymethylene, alkylaryl, alkoxyaryl, or alkoxycarbonyl linker was synthesized. The electrochemical study by cyclic voltammetry was carried out for two synthesized ligands, and the formation of the complexes with Cu(MeCN)ClO4 in the solution or on the gold electrode surface was established. The complex of Cu-I with 1,24-bis[N,N-bis(2-pyridylmethyl)-glycinoyloxy]-12,13-dithiatetracosane chemisorbed on the Au electrode is capable of binding molecular oxygen from solution. [ DOI ]

Bogdanova Y. G., Dolzhikova V. D., Mazhuga A. G. Polyolefin ketones adhesive characteristics in model systems polymer-liquid // Polymer Science - Series D. — 2011. — Vol. 4, no. 1. — P. 8–12.

Protonation of zwitter-ionic manganese and rhenium phosphoniostyryl complexes (i·5-c5h5)(co) 2m–c(+pr3)=c(h)ph: Experimental and dft study / V. V. Krivykh, D. A. Valyaev, K. I. Utegenov et al. // European Journal of Inorganic Chemistry. — 2011. — Vol. 2011, no. 2. — P. 201–211. Stereoselective addition of tertiary phosphanes to manganese and rhenium phenylvinylidenes (I·5-C5H5)(CO) 2M=C=C(H)Ph (1 M = Mn; 2 M = Re) gave the corresponding zwitterionic Z-phosphoniostyryl adducts (I·5-C5H 5)(CO)2M–C(+PR3)=C(H)Ph (3 M = Mn, PR3 = PPh2Me; 4 Mn, PPhMe2; 5 Mn, PMe3; 6 Re, PPh2Me; 7 Re, PMe3). Protonation of 3-7 with HBF4·OEt2 resulted in the formation of the I·2-phosponioalkene complexes (I·5- C5H5)(CO)2M(I·2-E-HC( +PR3)=C(H)Ph) (8 Mn, PPh2Me; 9 Mn, PPhMe 2; 10 Mn, PMe3; 11 Re, PPh2Me; 12 Re, PMe 3) rather than in the corresponding phosphoniocarbene complexes (I·5-C5H5)(CO)2M=C( +PR3)CH2Ph. It was shown by DFT calculations (B3LYP/6-31G*) that the protonation of 5 proceeds at the metal atom followed by C,H-reductive elimination in the intermediate hydride cis-(I·5-C5H5)(CO)2(H)Mn- C(+PMe3)=C(H)Ph (14) to form the agostic complex (I·5-C5H5)(CO)2Mn{I· 2-H-C(+PMe3)=C(H)Ph} (15) and subsequent isomerization of the latter into the final I·2- phosphonioalkene 10. In line with the theoretical data, the low-temperature protonation (-80oC) of 3 with triflic acid in an NMR tube directly gave the corresponding phosponioalkene complex 8. Unlike 3, the protonation of their rhenium analogues 6 and 7 under the same conditions revealed the quantitative formation of cis-hydride intermediates cis-[(I·5-C 5H5)(CO)2(H)Re-C(+PR 3)=C(H)Ph]OTf (16, 17), which undergo conversion into the corresponding I·2-phosponioalkene complexes 11 and 12 at ca. -30oC Protonation of Mn and Re Z-σ-phosphoniostyryl complexes 3-7 with HBF4·OEt2 leads to the E-I·2- phosphonioalkene derivatives 8-12 rather than the phosphoniocarbene complexes 13. According to DFT calculations, protonation of Mn complex 5 proceeds at the metal atom followed by fast conversion of the resulting cis-hydride 14 into the agostic intermediate 15 and the final product 10. Quantitative formation of the cis-hydride intermediates 16 and 17 was evidenced by low-temperature protonation of the rhenium Z-σ-phosphoniostyryl complexes 6 and 7 with triflic acid. [ DOI ]

Ultradispersed diamond as an excellent support for pd and au nanoparticle based catalysts for hydrodechlorination and co oxidation / E. V. Golubina, E. S. Lokteva, A. G. Majouga et al. // Diamond and Related Materials. — 2011. — Vol. 20, no. 7. — P. 960–964. The present study is aimed at the investigation of the catalytic performance of Pd or Au supported on ultradispersed diamond (UDD) catalysts in reductive and oxidative conditions. Very high catalytic activity of Pd or Au supported on ultradispersed diamond (UDD) was observed, in hydrodechlorination and CO oxidation, respectively. Specifically, Pd/UDD shows remarkable selectivity in the hydrodechlorination of 1,3,5-trichlorobenzene (benzene was the main product already at 30% TCB conversion and became the only product after 30 minutes of the reaction), substantially exceeding the performance of Pd supported on activated carbon and commercial 5% Pd/C references. It is proposed that this behavior is linked to the O-containing functional groups at the UDD surface, as detected via IR and EDX/SEM mapping, combined with a very small (6-7 nm by XRD) particle size of UDD support. (C) 2011 Elsevier B.V. All rights reserved. [ DOI ]

Unusual result of the reaction of 4-(1-methyl-1h-imidazol-2-yl)methylene-substituted 2-alkylthioimidazol-5(4h)-one with copper(ii) chloride / А. В. Юдина, А. Г. Мажуга, Е. К. Белоглазкина et al. // Russian Chemical Bulletin. — 2011. — Vol. 60, no. 10. — P. 2120–2123.

Новый наногибридный функциональный материал для ВЭЖХ на основе наночастиц золота, стабилизированных l-цистеином / И. А. Ананьева, Я. А. Елфимова, А. Г. Мажуга и др. // Сорбционные и хроматографические процессы. — 2011. — Т. 11, № 2. — С. 281–291.

Energy characteristics of poly(olefin ketone) surfaces at different interfaces / Y. G. Bogdanova, V. D. Dolzhikova, A. G. Mazhuga et al. // Russian Chemical Bulletin. — 2010. — Vol. 59, no. 7. — P. 1343–1348. [ DOI ]

Formation of palladium(ii) complex with triarylphosphine ligand on the surface of gold electrode modified with di(11-hydroxyundecyl)disulfide. cyclic voltammetry study / E. K. Beloglazkina, A. G. Mazhuga, R. D. Rakhimov, N. V. Zyk // Russian Journal of General Chemistry. — 2010. — Vol. 80, no. 2. — P. 227–231. Using the method of cyclic voltammetry the possibility of formation of the Pd(II) complex with triarylphosphine ligand on the gold electrode surface is shown resulting from the following sequence of reactions: (1) formation of the self-organized monolayer (SOM) of di(11-mercaptoundecyl)disulfide on the Au surface; (2) esterification of terminal hydroxy groups of the formed SOM with diphenyl(p-carboxyphenyl) phosphine; (3) formation of the complex compound fixed on the surface by treatment of the modified electrode with solution of PdCl(2) in CH(3)CN. The possibility of electrocatalytic reduction of iodobenzene on the gold electrode with participation of the obtained Pd(II) complex is demonstrated. [ DOI ]

N,n '-bis(2-mercaptophenyl)propane-1,3-diamine as a new organic ligand of the n2s2 type and its coordination compound with nickel(ii) / V. V. Frolov, A. G. Mazhuga, E. K. Beloglazkina et al. // Russian Chemical Bulletin. — 2010. — Vol. 59, no. 3. — P. 544–549. A method for the synthesis of new tetradentate organic ligand of the N2S2 type, viz., N,N'-bis-(2-mercaptophenyl) propane-1,3-diamine has been developed, starting from 2-(tert-butyl-thio) aniline and malonyl dichloride. Coordination compound of this ligand with Ni-II according to the X-ray diffraction data has a square-planar geometry of the metal ion coordination sphere.

New organic ligands of the terpyridine series: Modification of gold nanoparticles, preparation of coordination compounds with cu(i), catalysis of oxidation reactions / A. G. Majouga, R. B. Romashkina, A. S. Kashaev et al. // Chemistry of Heterocyclic Compounds. — 2010. — Vol. 46, no. 9. — P. 1076–1083. Organic ligands containing terpyridine and disulfide groupings linked between one another by a bonding -O(CH(2))(n)- (n = 6, 12) fragment have been synthesized. Gold nanoparticles of mean size 1.8 nm modified with the indicated ligand were obtained by the method of Brust. By methods of electron spectroscopy and cyclic voltamperometry, the possibility of forming of coordinated compounds on the surface of gold nanoparticles modified by a terpyridine ligand, on interaction with Cu(MeCN)(4)ClO(4) has been shown. The obtained nanoparticles catalyze the oxidation of 2,4-di-tert- butylphenol into 3,3', 5,5'-tetra(tert-butyl) biphenyl-2,2'-diol. [ DOI ]

New self-assembled monolayer coated cantilever for histidine-tag protein immobilization / P. V. Gorelkin, D. S. Mukhin, A. G. Majouga et al. // Mendeleev Communications. — 2010. — Vol. 20, no. 6. — P. 329–331. A new way to histidine-tag protein immobilization with a new type of terpyridine ligand, 4'-(12-mercaptododecanyloxy)-[2,2';6',2"]terpyridine, on gold coated cantilever has been proposed. [ DOI ]

New separation materials based on gold nanoparticles / A. Majouga, D. Pichugina, I. Ananieva et al. // Journal of Manufacturing Technology Management. — 2010. — Vol. 21, no. 8. — P. 950–955. Purpose – Gold clusters supported on oxide surface are most promising as active sites as biochemical sensors, in optical industry and catalysis, but there is no information about application of these nanoparticles in analytical chemistry for the chromatographical separation of organic compounds. Thus, the aim of this paper is the development of new separation systems based on gold nanoparticles. Design/methodology/approach – The novel nanohybride system based on gold nanoparticles, cysteine and inorganic matrixes was synthesis. The results were obtained by the combined approach consisting quantum-chemical calculations, direct organic synthesis and using chromatography investigation of obtained sorbent for separation of aminopyridines. Findings – The structure optimization of cysteine-gold cluster complexes reveals that adsorbed acid greatly changes the structure of gold nanoparticle and, consequently, changes its properties. The most bond energy is calculated for L-form 82 kcal/mol. Material based on alumina, modified gold nanoparticle with L-cysteine was synthesized and capacity coefficients for model compounds majoring by chromatography technique were obtained. Practical implications – The developed sorbent that consists of alumina, gold nanoparticle and organic ligand (L-cysteine) can used in analytical chemistry for the chromatographical separation of aminopyridine. The material has same advantages: simple sorbent synthesis, stability and repeatability in separation experimental. The presented novel nanohybride system is protected by Russian patent. Originality/value – The paper presents a successful application of nanogold for analytical separation of organic compounds, new knowledge about properties of gold in nanosized region and information about bonding sulfur with nanocluster’s surfaces, obtained by model physical-chemistry. [ DOI ]

Role of deposition technique and support nature on the catalytic activity of supported gold clusters: experimental and theoretical study / E. V. Golubina, D. A. Pichugina, M. Alexander, S. A. Aytekenov // Studies in Surface Science and Catalysis. — Vol. 175 of Scientific Bases for the Preparation of Heterogeneous Catalysts, Proceedings of the 10th International Symposium, Louvain-la-Neuve, Belgium, July 11-15, 2010. — Elsevier B.V Netherlands, 2010. — P. 297–300.

Synthesis and characterization of terpyridine-type ligand-protected gold-coated fe3o4 nanoparticles / P. G. Rudakovskaya, E. K. Beloglazkina, A. G. Majouga, N. V. Zyk // Mendeleev Communications. — 2010. — Vol. 20, no. 3. — P. 158–160. The three-step synthesis of new magnetic terpyridine-type ligand-protected gold-coated iron oxide nanoparticles (Fe3O4@Au-L) with an average size of 30 nm has been proposed, and their properties have been investigated. [ DOI ]

Ti new self-assembled monolayer coated cantilever for histidine-tag protein immobilization / M. A. Gorelkin,  Majouga,  Romashkina et al. // Mendeleev Communications. — 2010. — Vol. 20, no. 6. — P. 331–339. 4'-(12-mercaptododecanyloxy)-[2,2';6',2"]terpyridine, on gold coated cantilever has been proposed. TC 0 Z9 0 SN 0959-9436 UT WOS:000285910800009 ER.

Ti synthesis and characterization of terpyridine-type ligand-protected gold-coated fe3o4 nanoparticles /  Rudakovskaya,  Beloglazkina,  Majouga, G. Zyk // Mendeleev Communications. — 2010. — Vol. 20, no. 3. — P. 158–160. TC 3 Z9 3 SN 0959-9436 UT WOS:000279524500012 ER.

Богданова Ю. Г., Должикова В. Д., Мажуга А. Г. Адгезионные характеристики полиолефинкетонов в модельных системах полимер-жидкость // Клеи. Герметики. Технологии. — 2010. — № 7. — С. 2–7.

Металлические наночастицы / Н. С. Зефиров, Н. В. Зык, Е. К. Белоглазкина и др. // Проблемы Российской нанотехнологии" (серия "Академия наук - учителям", составители Н.В. Губина, И.Б. Морзунова, Е.Н. Тихонова). — Дрофа Москва, 2010. — С. 236–246.

Программа элективного курса "Нанотехнология в химии" (24 ч) / Н. С. Зефиров, Н. В. Зык, Е. К. Белоглазкина и др. // Проблемы Российской нанотехнологии" (серия "Академия наук - учителям", составители Н.В. Губина, И.Б. Морзунова, Е.Н. Тихонова). — Дрофа Москва, 2010. — С. 45–50.

Программа элективного курса "Нантехнология и наноиндустрия" (36 ч) / Н. С. Зефиров, Н. В. Зык, Е. К. Белоглазкина и др. // Проблемы Российской нанотехнологии" (серия "Академия наук - учителям", составители Н.В. Губина, И.Б. Морзунова, Е.Н. Тихонова). — Дрофа Москва, 2010. — С. 51–56.

Программа элективного курса "Основы нанотехнологии" (12 ч) / Н. С. Зефиров, Н. В. Зык, Е. К. Белоглазкина и др. // Проблемы Российской нанотехнологии" (серия "Академия наук - учителям", составители Н.В. Губина, И.Б. Морзунова, Е.Н. Тихонова). — Дрофа Москва, 2010. — С. 41–44.

Самоорганизация молекул на поверхности и ее использование в нанотехнологии / Н. С. Зефиров, Н. В. Зык, Е. К. Белоглазкина и др. // Проблемы Российской нанотехнологии" (серия "Академия наук - учителям", составители Н.В. Губина, И.Б. Морзунова, Е.Н. Тихонова). — Дрофа Москва, 2010. — С. 247–269.

Энергетические характеристики полиолефинкетонов на различных межфазных границах / Ю. Г. Богданова, В. Д. Должикова, А. Г. Мажуга и др. // Известия Академии наук. Серия химическая. — 2010. — № 7. — С. 1313–1318.

4-alkoxycarbonyl-2-(2-pyridyl)thiazoles and their complexes with cu-ii and co-ii. molecular and crystal structure of copper 4-ethoxycarbonyl-2-(2-pyridyl)thiazole dichloride / A. G. Majouga, E. K. Beloglazkina, V. V. Frolov et al. // Russian Chemical Bulletin. — 2009. — Vol. 58, no. 4. — P. 844–850. The first synthesis of ethyl 2-(2-pyridyl)thiazole4-carboxylate ( 2) and bis[2-(2-pyridylthiazol-4-ylcarbonyloxy)ethyl] disulfide ( 4) is described. The complexation of compounds 2 and 4 with Cu-II, Co-II, and Ni-II chlorides and perchlorates has been studied. Electrochemical behavior of the ligands and complexes obtained has been investigated by cyclic voltammetry and using rotating disk electrode, which allowed us to confirm the possibility for the ligand 4 and its complexes to be adsorbed on the surface of a gold electrode. [ DOI ]

First example of the ring-opening transformation of thiazolidines to iminothiols on gold surface / A. G. Majouga, E. K. Beloglazkina, I. V. Yudin et al. // Mendeleev Communications. — 2009. — Vol. 19, no. 2. — P. 92–93. A new way to construction of the self-assembling monolayers on gold surfaces based on ring opening reactions of thiazolidines to iminothiols followed by Au-S bond formation has been proposed. [ DOI ]

Formation of cu-i(ch3cn)(4)clo4 in the reactions of copper(ii) perchlorate with acetonitrile in the presence of sulfur-containing organic compounds / E. K. Beloglazkina, A. V. Shimorsky, A. G. Mazhuga et al. // Russian Journal of General Chemistry. — 2009. — Vol. 79, no. 7. — P. 1504–1508. Cu(ClO4)(2)center dot 6H(2)O was shown to react with 2,2'-[propane-1,3-diylbis(thio-2-phenylnemethylidene]-bis(3-pyridylamine ) (1) or (5Z)-2-ethoxycarbonylmethyl-(2-pyridylmethylidene)-3,5-dihydro-4H-imidaz ol-4-one (II) in the presence of CH3CN with the reduction of copper(II) to copper(l) and the formation of the tetrahedral complex Cu-I(CH3CN)(4)ClO4 (III). In the course of the reaction the organic ligands I and If were oxidized to the corresponding sulfoxides. [ DOI ]

Oxidation of triphenylphosphine and norbornene by nitrous oxide in the presence of (colcl2)-l-ii [l=3-phenyl-5-(2-pyridylmethylidene)-2-thiohydantoin]: the first example of co-ii-catalyzed alkene oxidation by n2o / E. K. Beloglazkina, A. G. Majouga, A. A. Moiseeva et al. // Mendeleev Communications. — 2009. — Vol. 19, no. 2. — P. 69–71. New catalytic oxidation reactions using N2O as an oxidant and a COCl2 Complex with 3-phenyl-5-(2-pyridylmethylidene)-2-thiohydantoin as a catalyst are described. [ DOI ]

Ti oxidation of triphenylphosphine and norbornene by nitrous oxide in the presence of (colcl2)-l-ii [l=3-phenyl-5-(2-pyridylmethylidene)-2-thiohydantoin]: the first example of co-ii-catalyzed alkene oxidation by n2o /  Beloglazkina,  Majouga,  Zyk, N. S. Zefirov // Mendeleev Communications. — 2009. — Vol. 19, no. 2. — P. 69–71.

Ti tetradentate nitrogen-containing ligands bis-5-(2-pyridylmethylidene)-3,5-dihydro-4h-imidazol-4-ones and their coordination compounds with cu-i and cu-ii /  Majouga,  Beloglazkina,  Shilova et al. // Russian Chemical Bulletin. — 2009. — Vol. 58, no. 7. — P. 1392–1399.

Tetradentate diamido-bis-sulfide ligands on the base of o-aminobenzenethiol and their complexation with ni-ii, co-ii, cu-ii chlorides in dmf solution and on the gold electrode surface / E. K. Beloglazkina, A. G. Majouga, F. S. Moiseev et al. // Russian Chemical Bulletin. — 2009. — Vol. 58, no. 8. — P. 1707–1712. A series of cyclic and acyclic diamido-bis-sulfide ligands were synthesized by N-acylation of 1,2-bis(2-aminophenylthio)ethane and 1,4-bis(2-aminophenylthio)butane with acetic, malonic, and 3,3'-dithiodipropionic acid chlorides or esters. The complexation of obtained ligands with Cu-II, Ni-II, and Co-II salts in solution and on the gold electrode surface was studied. The formation of complexes of these ligands with copper(II) chloride in DMF is irreversible and accompanied by deprotonation of the amide nitrogen atoms. [ DOI ]

Tetradentate nitrogen-containing ligands bis-5-(2-pyridylmethylidene)-3,5-dihydro-4h-imidazol-4-ones and their coordination compounds with cu-i and cu-ii / A. G. Majouga, E. K. Beloglazkina, O. V. Shilova et al. // Russian Chemical Bulletin. — 2009. — Vol. 58, no. 7. — P. 1392–1399. Tetradentate N-4-type organic ligands containing two 5-(2-pyridylmethylidene)-2-thio-3,5-dihydro-4H-imidazol-4-one fragments linked by two-, four-, or six-carbon polymethylene bridges between the sulfur atoms were synthesized. Mono- and dinuclear complexes of these ligands with copper(II) chloride, as well as with copper(I) and copper(II) perchlorates, were prepared. The structure of the coordination compound (5Z,5'Z)-2,2'-(butane-1,2-diyl-disulfanyldiyl)bis-5-(2-pyridylmethyliden e)-3-phenyl-3,5-dihydro-4H-imidazol-4-one with copper(I) perchlorate was established by X-ray diffraction. The copper atom in this complex is in a distorted tetrahedral coordination formed by four nitrogen atoms of two imidazole and two pyridine rings. The perchlorate anion is located in the outer sphere of the complex and is not involved in the coordination with the copper ion. The electrochemical study of the ligands and the complexes was carried out by cyclic voltammetry and rotating disk electrode voltammetry. The initial reduction of the complexes under study occurs at the metal atom. The length of the polymethylene bridge in the ligand has only a slight effect on the redox properties of the ligands and the complexes. [ DOI ]

Use of gold nanoparticles for immobilization of l-cysteine on tlc plates / E. N. Shapovalova, I. A. Ananieva, A. G. Majouga et al. // Moscow University Chemistry Bulletin. — 2009. — Vol. 64, no. 3. — P. 159–164.

Применение наночастиц золота для иммобилизации l-цистеина на пластинки для тонкослойной хроматографии / Е. Н. Шаповалова, И. А. Ананьева, А. Г. Мажуга и др. // Вестник Московского университета. Серия 2: Химия. — 2009. — Т. 50, № 3. — С. 200–207.

Тетрадентатные диамидо-бис-сульфидные лиганды на основе орто-аминотиофенола и их комплексообразование с хлоридами ni(ii), co(ii), cu(ii) в растворе ДМФА и на поверхности золотого электрода / Е. К. Белоглазкина, А. Г. Мажуга, Ф. С. Моисеев и др. // Известия АН СССР, Серия Химическая. — 2009. — № 8. — С. 1655–1660.

A new method for the synthesis of 5-bromo(aryl)methylene-substituted hydantoins / R. L. Antipin, E. K. Beloglazkina, A. G. Magouga et al. // Chemistry of Heterocyclic Compounds. — 2008. — Vol. 44, no. 9. — P. 1135–1137. It has been shown that bromination of 5-aryl-5-benzylidene-3,5-dihydro-4H-2-methylthioimidazol-4-one in methylene chloride at room temperature leads to the addition of bromine at the double bond, but the the reaction of 5-aryl-3,5-dihydro-4H-2-methylthio-5-(2-pyridylmethylene)imidazol-4-one gave complex compound of the starting materials. After boiling both of the compounds obtained in ethanol the corresponding 5-[bromo(aryl)methylene]imidazolidine-2,4-diones were obtained. [ DOI ]

Coordination properties of 1,3-benzothiazoles. formation of a polymeric complex with square-planar coordination around the copper(ii) ion in the reaction of cucl2 center dot 6h(2)o with 1,2-bis[2-(1,3-benzo-thiazol-2-yl)phenylthio]ethane / E. K. Beloglazkina, A. V. Shimorskiy, A. G. Majouga, N. V. Zyk // Chemistry of Heterocyclic Compounds. — 2008. — Vol. 44, no. 10. — P. 1284–1287. It is shown that a coordination polymer is formed by the reaction of 1,2-bis[2-(1,3-benzothiazol-2-yl)-phenylthio]ethane with copper(II) chloride in a mixture of ethanol and chloroform at room temperature. The structure of the polymer has been determined by X-ray crystallography. The copper atom in the coordination polymer has a square-planar ligand environment and is coordinated to the nitrogen atoms of the benzothiazole rings of two different molecules of ligand and two chloride anions. [ DOI ]

Synthesis and electrochemical characterization of complexes of 1,2-bis[2-(pyridylmethylideneamino)phenylthio]ethanes with transition metals (co-ii, ni-ii, cu-ii) / E. K. Beloglazkina, A. G. Majouga, A. A. Moiseeva et al. // Russian Chemical Bulletin. — 2008. — Vol. 57, no. 2. — P. 358–363. Transition metal (Ni-II, Co-II, and Cu-II) complexes with 1,2-bis[2-(3-pyridylmethylideneamino)phenylthio]ethane (1) and 1,2-bis[2-(4-pyridylmethylideneamino)phenylthio]ethane (2) were synthesized for the first time by slow diffusion of solutions of compounds 1 or 2 in CH2Cl2 into solutions of MX2 center dot nH(2)O (M = Ni, Co, or Cu; X = Cl or NO3; n = 2 or 6) in ethanol. The reactions with Co-II and Cu-II chlorides afford complexes of composition M(L)Cl-2 (L = 1 or 2). The reactions of compound 1 with Ni-II salts produce complexes with 1,2-bis(2-aminophenylthio)ethane. The molecular structure of dinitrato[1,2-bis(2-aminophenylthio)ethane]nickel(ii) was confirmed by X-ray diffraction. The ligands and the complexes were investigated by cyclic voltammetry and rotating disk electrode voltammetry. The initial reduction of the complexes proceeds at the metal atom. The oxidation of the chlorine-containing complexes proceeds at the coordinated chloride anion. [ DOI ]

Synthesis and electrochemical study of 3-and 4-(2-pyridyl)-1,3-benzothiazole complexes with transition metals (co-ii, ni-ii, and cu-ii). molecular structure of bis{(4-(2-pyridyl)-1,3-benzothiazole)copper(ii)} tetraacetate / E. K. Beloglazkina, I. V. Yudin, A. G. Mazhuga et al. // Russian Chemical Bulletin. — 2008. — Vol. 57, no. 3. — P. 577–584. A series of the M(L)Cl-2 center dot H2O and {M(L)}(2)(OAc)(4) complexes (M = Ni-II ,Co-II, and Cu-II; L is 3- and 4-(2-pyridyl)-1,3-benzothiazole) were synthesized by the reaction of L with MX2 center dot nH(2)O (X = Cl, OAc) in ethanol. The molecular and crystal structures of the CuL2(OAc)(4) binuclear complex (L is 4-(2-pyridyl)benzothiazole) were determined by X-ray diffraction analysis. The copper atoms have a distorted tetragonal bipyramidal environment and are coordinated to the nitrogen atom of the pyridine moiety of the ligand and to two oxygen atoms of the bridging acetate ligands. The Cu-Cu distance is 2.6129(9) angstrom. The electrochemical behavior of the synthesized ligands and complexes was studied using the cyclic voltammetry and rotating disk electrode techniques in DMF Solutions (0.1 M Bu4NClO4). The primary reduction of all the complexes tinder study is directed to the metal.

Ti coordination properties of 1,3-benzothiazoles. formation of a polymeric complex with square-planar coordination around the copper(ii) ion in the reaction of cucl2 center dot 6h(2)o with 1,2-bis[2-(1,3-benzo-thiazol-2-yl)phenylthio]ethane / E. K. Beloglazkina, A. V. Shimorskiy, A. G. Majouga, N. V. Zyk // Chemistry of Heterocyclic Compounds. — 2008. — Vol. 44, no. 10. — P. 1284–1287.

Ti synthesis and electrochemical characterization of complexes of 1,2-bis[2-(pyridylmethylideneamino)phenylthio]ethanes with transition metals (co-ii, ni-ii, cu-ii) / E. K. Beloglazkina, A. G. Majouga, A. A. Moiseeva et al. // Russian Chemical Bulletin. — 2008. — Vol. 57, no. 2. — P. 358–363.

5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one and its complexes with transition metals (co-ii, ni-ii, and cu-ii). synthesis and electrochemical investigation / E. K. Beloglazkina, A. G. Majouga, A. A. Moiseeva et al. // Russian Chemical Bulletin. — 2007. — Vol. 56, no. 2. — P. 351–355. The reaction of 5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin 4-one (LH) with salts MCl2 center dot xH(2)O (M = Co, Ni, Cu; x = 2, 6) afforded the [M(L)Cl](n) complexes of Ni-II, Co-II, and Cu-II. The electrochemical behavior of the LH ligand and its complexes was studied using the cyclic voltammetry and rotating disk electrode techniques. The structures of the synthesized compounds were determined by the data of UV-Vis and IR spectroscopy, mass spectrometry, and electrochemical characteristics. [ DOI ]

Bis-(4-(2-pyridylmethyleneiminophenyl))disulfide - a chelating ligand capable of self assembly on gold surface and its complexes with m(bf4)(2) and m(clo4)(2); m=co, cu and ni. experimental and theoretical study / E. K. Beloglazkina, A. G. Majouga, N. V. Zyk et al. // Thin Solid Films. — 2007. — Vol. 515, no. 11. — P. 4649–4661.

First organic-inorganic hybrid material based on agno3 and 3-pyridine containing 2-thiohydantoin / S. Z. Vatsadze, A. G. Majouga, E. K. Beloglazkina et al. // Mendeleev Communications. — 2007. — Vol. 17, no. 2. — P. 77–79.

N,s,o-containing organic ligands based on salicylaldehyde and 2-thiosubstituted ethylamines and their complexes with co-ii, ni-ii, and cu-ii / E. K. Beloglazkina, A. G. Majouga, A. N. Chernysheva et al. // Russian Chemical Bulletin. — 2007. — Vol. 56, no. 7. — P. 1374–1379. The reaction of 2,2'-di(2-hydroxybenzaliminoethyl) disulfide (H2L1) and 2-[(2-thioethyl)iminomethyl]phenol (H2L2) with MCl2 center dot xH(2)O (M = Co, Ni, Cu) afforded the [M-2(L-1)Cl-2] and [M(L-2)](2) complexes, respectively. Their structures were determined by the data of electronic and IR spectroscopy and PM3 quantum chemical calculations. The H2L1 ligand and the complexes were studied by electrochemistry (CV and using a rotating disk electrode). The primary electronic changes are localized on the ligand fragment upon the electrochemical oxidation and reduction of the complexes. [ DOI ]

Synthesis and electrochemical characterization of co-ii, ni-ii, and cu-ii complexes with organic n2s2-type ligands derived from 2-thio-substituted benzaldehydes and aromatic amines / E. K. Beloglazkina, A. V. Shimorsky, A. G. Majouga et al. // Russian Chemical Bulletin. — 2007. — Vol. 56, no. 11. — P. 2189–2199. Transition metal complexes (Ni-II, Co-II, and Cu-II) with tetradentate N2S2-type ligands ( L), which are reaction products of 2-thio-substituted benzaldehydes with aromatic amines (3-aminopyridine or 2-aminothiophenol), were synthesized for the first time. The complexes have the composition L center dot MX2 or L center dot 2MX(2) (X = Cl or ClO4). The electrochemical behavior of the ligands and complexes was studied by cyclic voltammetry and rotating disk electrode voltammetry. Depending on the structure of the complexes, the metal atom in the latter is initially reduced in a one- or two-electron process. [ DOI ]

Ti 5-[2-(methylthio)ethyl]-3-phenyl-2-thioxoimidazolidin-4-one and its complexes with transition metals (co-ii, ni-ii, and cu-ii) / E. K. Beloglazkina, A. G. Majouga, A. A. Moiseeva et al. // Russian Chemical Bulletin. — 2007. — Vol. 56, no. 2. — P. 351–355.

Ti n,s,o-containing organic ligands based on salicylaldehyde and 2-thiosubstituted ethylamines and their complexes with co-ii, ni-ii, and cu-ii / E. K. Beloglazkina, A. G. Majouga, A. N. Chernysheva et al. // Russian Chemical Bulletin. — 2007. — Vol. 56, no. 7. — P. 1374–1379.

Ti synthesis and electrochemical characterization of co-ii, ni-ii, and cu-ii complexes with organic n2s2-type ligands derived from 2-thio-substituted benzaldehydes and aromatic amines / E. K. Beloglazkina, A. V. Shimorsky, A. G. Majouga et al. // Russian Chemical Bulletin. — 2007. — Vol. 56, no. 11. — P. 2189–2199.

5-(pyridylmethylidene)-substituted 2-thiohydantoins and their complexes with cu(ii), ni(ii) and co(ii): synthesis, electrochemical study and adsorption on the cystamine-modified gold surface / E. K. Beloglazkina, A. G. Majouga, I. V. Yudin et al. // Russian Chemical Bulletin. — 2006. — Vol. 55, no. 6. — P. 1–13.

5-(pyridylmethylidene)-substituted 2-thiohydantoins and their complexes with cu-ii, ni-ii, and co-ii: synthesis, electrochemical study, and adsorption on the cystamine-modified gold surface / E. K. Beloglazkina, A. G. Majouga, L. V. Yudin et al. // Russian Chemical Bulletin. — 2006. — Vol. 55, no. 6. — P. 1015–1027. A series of Cu-II, Ni-II, and Co-II complexes with 5-(pyridylmeth ylidene)-substituted 2-thiohydantoins (L) were synthesized by the reactions of the corresponding organic ligands with MCl2-nH(2)O. The resulting complexes have the composition LMCl2 (M = Cu(.)or Ni) or L2MCl2 (M = Co). The reactions with N(3)-unsubstituted thiohydantoins afford complexes containing four-membered metallacycles, in which the metal ion is coordinated by the S and N(3) atoms of the thiohydantoin ligand. The reactions of N(3)-substituted thiohydantoins give complexes in which the S and N(l) atoms are involved in coordination. Study by IR spectroscopy demonstrated that the pyridine nitrogen atom is not involved in coordination. Based on the results of electrochemical study of the ligands and complexes by cyclic voltammetry and calculation of their frontier orbitals by the PM3(tm) method, the mechanism of oxidation and reduction of these compounds was proposed. In the first reduction and oxidation steps, the metal atom in the copper and nickel complexes remains, apparently, intact, and these processes occur with the involvement of the ligand fragments, viz., the coordinated thiohydantoin ligand and chloride anion, respectively. In the cobalt complexes, the first reduction step occurs at the ligand; the first oxidation state, at the metal atom. Measurements of the contact angle of aqueous wetting and electrochemical study demonstrated that carboxy-containing 2-thiohydantoins and their complexes can be adsorbed on the cystamine-modified gold surface. The structures of the complexes on the surface differ from the structures of these complexes in solution. [ DOI ]

A novel catalyst for alkene epoxidation: a polymer-supported (colcl2)-l-ii {l=2-(alkylthio)-3-phenyl-5-(pyridine-2-ylmethylene)-3,5-dihydro-4h-imid azole-4-one} complex / E. Beloglazkina, A. Majouga, R. Romashkina, N. Zyk // Tetrahedron Letters. — 2006. — Vol. 47, no. 17. — P. 2957–2959.

Synthesis and electrochemical study of 2-(2-pyridyl)benzothiazole complexes with transition metals (co-ii, ni-ii, and cu-ii). molecular structure of aquabis[2-(2-pyridyl)benzothiazole]copper(ii) diperchlorate / E. K. Beloglazkina, I. V. Yudin, A. G. Majouga et al. // Russian Chemical Bulletin. — 2006. — Vol. 55, no. 10. — P. 1803–1809. The reactions of 2-(2-pyridyl)benzothiazole (1) with MX2 (.) nH(2)O salts (M = Ni-II, Co-II, or Cu-II; X = Cl or ClO4; n = 0-2) in EtOH afforded the corresponding complexes. Depending on the nature of the counterion in the starting metal salt, the reactions give compounds of composition M(1)Cl-2 (.) nH(2)O or Cu(1)(2)(ClO4)(2) (.) H2O. The molecular and crystal structure of the Cu-II(1)(2)(ClO4)(2) (.) H2O complex was established by X-ray diffraction. The copper atom in this complex has a distorted tetragonal -pyramidal ligand environment and is coordinated by four nitrogen atoms of two ligand molecules and one water molecule. Electrochemical study of the ligand and the resulting complexes by cyclic voltammetry and at a rotating disk electrode demonstrated that ligand 1 stabilizes reduced forms of complexes containing Ni, Co, or Cu atoms in the oxidation state + 1. [ DOI ]

Ti 5-(pyridylmethylidene)-substituted 2-thiohydantoins and their complexes with cu-ii, ni-ii, and co-ii: synthesis, electrochemical study, and adsorption on the cystamine-modified gold surface / E. K. Beloglazkina, A. G. Majouga, L. V. Yudin Frolova Zyk et al. // Russian Chemical Bulletin. — 2006. — Vol. 55, no. 6. — P. 1015–1027.

Ti synthesis and electrochemical study of 2-(2-pyridyl)benzothiazole complexes with transition metals (co-ii, ni-ii, and cu-ii). molecular structure of aquabis[2-(2-pyridyl)benzothiazole]copper(ii) diperchlorate / E. K. Beloglazkina, I. V. Yudin, A. G. Majouga et al. // Russian Chemical Bulletin. — 2006. — Vol. 55, no. 10. — P. 1803–1809.

2005 synthesis and electrochemical study of complexes of 2-methylthio-5-(pyridylmethylidene)-3,5-dihydro-4h-imidazol / E. K. Beloglazkina, S. Z. Vatsadze, A. G. Majouga et al. // Russian Chemical Bulletin. — 2005. — Vol. 54, no. 12. — P. 2771 –2782.

Synthesis and electrochemical study of complexes of 2-methylthio-5-(pyridylmethylidene)-3,5-dihydro-4h-imidazol / E. K. Beloglazkina, S. Z. Vatsadze, A. G. Majouga et al. // Russian Chemical Bulletin. — 2005. — Vol. 54, no. 12. — P. 2771–2782. New transition metal (Ni-II, Co-II, and Cu-II) complexes with 2-methylthio-5-(pyridylmetiiylidene)-3,5-dihydro-4H-imidazol-4-ones were synthesized by the reaction of 5-(alpha, beta-, or gamma-)pyridyl-substituted 2-methylthio-3,5-dihydro-4H-imidazol-4-ones with MCl2 (.) nH(2)O. In the complexes with alpha-Py-substituted ligands, the metal atom has a tetrahedral coordination environment and is coordinated by the nitrogen atoms of the pyridine and thiohydantoin rings and two chloride anions. The results of electronic spectroscopy and magnetic susceptibility measurements suggest that the complexes with the beta- and gamma-Py-substituted ligands have polymeric structures, and the metal atoms in these complexes are in an octahedral environment. The molecular and crystal structures of (COCl2)-Cl-II (L-1 is (5Z)-2-methylthio-3-phenyl-5-(alpha-pyridylmethylidene)-3,5-dihydro-4H-i midazol-4-one) and (CoLCl2)-L-II-Cl-2 (L-2 is (5Z)-3-methyl-2-metliyitliio-5-(alpha-pyridylmethylidene)-3,5-dihydro-4H -imidazol-4-one) were established by X-ray diffraction. Semiempirical quantum-chemical calculations were performed for 2-methylthio-5-(pyridylmethylidene)-3,5-dihydro-4H-imidazol-4-ones. The complexes, starting ligands, and metal chlorides were studied electrochemically. The mechanism of electrooxidation and electroreduction of 2-methylthio-5-(pyridylmethylidene)-3,5-dihydro-4-Himidazol-4-ones and their cobalt, nickel, and copper complexes was proposed. [ DOI ]

Synthesis and electrochemical study of complexes of 2-methylthio-5-(pyridylmethylidene)-3,5-dihydro-4h-imidazol / E. K. Beloglazkina, S. Z. Vatsadze, A. G. Majouga et al. // JOURNAL OF ANALYTICAL CHEMISTRY издательство Maik Nauka/ Interperiodica Publishing ( Russian Federation). — 2005. — Vol. 54, no. 12. — P. 2771–2782. DOI.

Synthesis and electrochemistry of (5z,5 ' z)-2,2 '-(alkane-alpha,omega-diyldisulfanyldiyl)-bis(5-(2-pyridylmethylene)-3,5 -dihydro-4h-imidazol-4-one) complexes with cobalt(ii) chloride / E. Belogiazkina, A. Majouga, I. Yudin et al. // Russian Chemical Bulletin. — 2005. — Vol. 54, no. 9. — P. 2163–2168.

The first example of a reversibly reducible co-ii complex with an anionic 2-thiohydantoin-type ligand / A. G. Majouga, E. K. Beloglazkina, S. Z. Vatsadze et al. // Mendeleev Communications. — 2005. — no. 2. — P. 48–50. The reaction of the potassium salt of 3-phenyl-5(Z)-(pyridin-2-ylmethylene)-2-thioxoimidazolidin-4-one (KL) with CoCl(2)center dot 6H(2)O in MeCN results in formation of the neutral complex (CoL2)-L-II. According to single-crystal X-ray analysis, the Coll centre is coordinated to four nitrogen atoms of two organic ligands and has a distorted tetrahedral geometry. This complex undergoes electrochemical reduction with consequent two reversible and one quasi-reversible stages. [ DOI ]

The first example of a reversibly reducible co-ii complex with an anionic 2-thiohydantoin-type ligand / A. Majouga, E. Beloglazkina, S. Vatsadze et al. // Mendeleev Communications. — 2005. — no. 2. — P. 48–50.

Синтез 3-пиридилзамещенных производных 2-тиогидантоина / А. Г. Мажуга, С. З. Вацадзе, Н. А. Фролова, Н. В. Зык // Вестник Московского университета. Серия 2: Химия. — 2005. — Т. 46, № 5. — С. 300–303. Реакцией пиридилдитиокарбамата триэтиламмония с аминокислотами были полу- чены неизвестные ранее производные 2-тиогидантоинов, содержащие пиридильные заместители.

Synthesis of isomeric 3-phenyl-5-(pyridylmethylene)-2-thiohydantoins and their s-methylated derivatives / A. G. Majouga, E. K. Beloglazkina, S. Z. Vatsadze et al. // Russian Chemical Bulletin. — 2004. — Vol. 53, no. 12. — P. 2850–2855. Three procedures were used for the synthesis of alpha-, beta-, and gamma-pyridyl-substituted (5Z)-3-phenyl-5-(pyridylmethylene)-2-thiohydantoins: the reaction of 2-thiohydantoin with the corresponding aldehyde in AcOH in the presence of AcONa, the two-step one-pot synthesis with the use of the same starting compounds, and three-component condensation of aryl isothiocyanate, glycine, and aldehyde in AcOH. Alkylation of the resulting thiohydantoins with iodomethane in the presence of a base afforded the corresponding S-methylated derivatives, viz., 2-methylthio-3-phenvl-5-(pyridylmethylene)-3,5-dihydro-4H-imidazo1-4-one s. The structures of (5Z)-3-phenyl-5-(pyridin-2-ylmethylene)-2-thioxoimidazolin-4-one and (5Z)-2-methylthio-3-phenyl-5-(pyridin-2-ylmethylene)-3,5 -dihydro-4H-imidazol-4-one were established by X-ray diffraction analysis. [ DOI ]

Synthesis, structure and electrochemistry of (colcl2)-l-ii center dot 0.5mecn{l = [2-(methylthio)-3-phenyl-5-(pyridin-2-ylmethylene)-3,5-dihydro-4h-imidaz ol-4-one]} / A. G. Majouga, E. K. Beloglazkina, S. Z. Vatsadze et al. // Mendeleev Communications. — 2004. — no. 3. — P. 115–117. The reaction of 2-(methylthio)-3-phenyl-5-(pyridin-2-ylmethylene)-3,5-dihydro-4H-imidazo l-4-one (L) with CoCl(2)(.)6H(2)O in MeCN-CH2Cl2 results in formation of the complex CoLCl(2)(.)0.5MeCN, which was characterised by single-crystal X-ray diffraction analysis and an electrochemical study. [ DOI ]

Synthesis, structure and electrochemistry of (colcl2)-l-ii center dot 0.5mecn{l = [2-(methylthio)-3-phenyl-5-(pyridin-2-ylmethylene)-3,5-dihydro-4h-imidaz ol-4-one]} / A. Majouga, E. Beloglazkina, S. Vatsadze et al. // Mendeleev Communications. — 2004. — no. 3. — P. 115–117.

Supramolecular design of one-dimensional coordination polymers based on silver(i) complexes of aromatic nitrogen-donor ligands / A. Khlobystov, A. Blake, N. Champness et al. // Coordination Chemistry Reviews. — 2001. — Vol. 222. — P. 155–192. [ DOI ]

Novel sulfo-sulfenylating reagents based on s-so2-containing compounds / N. V. Zyk, E. K. Beloglazkina, A. G. Mazhuga, N. S. Zefirov // Russian Chemical Bulletin. — 2000. — Vol. 49, no. 5. — P. 960–961. [ DOI ]

An improved preparation of 4-ethynylpyridine and its application to the synthesis of linear bipyridyl ligands / N. R. Champness, A. N. Khlobystov, A. G. Majuga et al. // Tetrahedron Letters. — 1999. — Vol. 40, no. 29. — P. 5413–5416. A convenient synthesis of 4-ethynylpyridine, 5, starting from 4-vinylpyridine has been developed. Compound 5 reacts readily with pyridyl- and aryl-iodides to give the linear bidentate ligands 7, 9, and 11 in excellent yields. (C) 1999 Elsevier Science Ltd. All rights reserved. [ DOI ]

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