Преподаватели и сотрудники

Кочетков Константин Александрович

Занимаемые должности

Профессор (Кафедра химии и технологии биомедицинских препаратов)

Телефон

8-495-495-13-27

E-mail

const1949@muctr.ru

Сайт https://muctr.ru
Уровень образования Высшее
Квалификация

Химик

Преподаваемые дисциплины

Современные методы физико-химического анализа органических веществ

Применеических методов анализа при синтезе и производстве биологически активных веществ

Современные методы и направления в получении биомедицинских препаратов

Учёная степень

Доктор химических наук

Наименование направления подготовки и (или) специальности

Органическая химия

Общий стаж работы 5 лет (с 01.02.2014)
Стаж работы по специальности 5 лет (с 01.02.2014)

Публикации

Урюпин А. Б., Кочетков К. А. "Химические аспекты потребления табака.Часть 20. Химические средства в современной системе обеспечения производства продукции на основе растения табака nicotiana tabacum l (ч.2)в журнале tobacco Ревю, №2, с.32-34 // Tobacco Ревю. — 2019. — № 2. — С. 32–34. Продолжение обзора, опубликованного в №1.

Alternative synthetic route to a conformationally stable c,n-palladacycle / O. N. Gorunova, Y. K. Grishin, K. A. Kochetkov, V. V. Dunina* // ИНЭОС OPEN. — 2019. — Vol. 2, no. 2. — P. 45–49. An efficient synthetic route to two enantiomers of α-tertbutyl- substituted benzylaminate C,N-palladacycle is developed based on the separation of diastereomers of its (S)-prolinate derivative. The possibility of application of the (S)-prolinate intermediate for estimation of conformational stability and definition of an absolute configuration of the palladacycle is demonstrated. [ DOI ]

Alkylation of cimantrene with 1-bromoadamantane initiated by iron pentacarbonyl / Т. Т. Васильева, H. H. Hambardzumyan, N. Е. Mysova et al. // ИНЭОС OPEN. — 2019. — Vol. 2, no. 1. — P. 29–32. Инициирование пентакарбонилом железа алкилирования цимантрена 1-бромадамантаном приводит к образованию адамантилцимантрена, 1,3-диадамантилцимантрена, 1-(3-бромадамантил)-3-адамантилцимантрена, бромадамантилцимантрена. [ DOI ]

Catalytic mechanisms of reactions of tryptophan indole-lyase with non-standard substrates. the role of ionic state of catalytic group accepting c-proton of the substrate / N. G. Faleev, M. A. Tsvetikova, O. I. Gogoleva et al. // Acta Naturae (англоязычная версия). — 2019. — Vol. 11, no. 3. — P. 169–175. In the reaction of tryptophan indole-lyase (TIL) with a substrate containing bad leaving group (L-serine) general acid catalysis is necessary for its elimination. During this stage the proton, originally bound to C- atom, is transferred to the leaving group which is eliminated as a water molecule. As a result, the basic group, which in the course of the previous stage had accepted the C-proton, should participate in the stage, following the elimination, in its basic form. On the other hand, when the substrate contains a good leaving group (-chloro-L-alanine), the general acid catalysis on the stage of elimination is not needed and cannot be realized, because in enzymes there are no functional groups whose acidity is great enough to protonate a base as weak as Cl- anion being eliminated., Consequently, the group, which had accepted the C-proton, does not lose its additional proton during elimination stage, and should take part in the subsequent sage in its acidic (not basic) form. To shed light on the mechanistic consequences of the change of the ionic state of this group we have considered pH-dependencies of the main kinetic parameters for the reactions of TIL with L-serine and -chloro-L-alanine and kinetic isotope effects brought about by the change of ordinary water as a solvent for 2H2O. We have found that in the reaction of TIL with -chloro-L-alanine the stage of aminoacrylate hydrolysis is sensitive to solvent isotope effect, while in the reaction with L-serine it is not. We have concluded that in the first reaction the functional group containing the additional proton fulfills a definite catalytic function whereas in reaction with L-serine, when additional proton is absent, the mechanism of hydrolysis of aminoacrylate intermediate should be principally different. Possible mechanisms were considered.

The use of iron carbonyls in the c—c bond formation reactions / K. A. Kochetkov, T. T. Vasil’eva, R. G. Gasanov et al. // Russian Chemical Bulletin, Springer-Verlag GmbH (Heidelberg). — 2019. — Vol. 68, no. 7. — P. 1301–1320. The material is systematized according to the principle of key types of reactions promoted by iron carbonyls, which are subdivided into several main areas, with the main focus on new examples of the use of iron carbonyls in the synthetic directions of the C – C bond formation reaction. [ DOI ]

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