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Преподаватели и сотрудники

Белов Алексей Алексеевич

Белов Алексей Алексеевич

Занимаемые должности

Профессор (Кафедра биотехнологии)

Телефон

8-495-495-23-79

E-mail

abelov2004@muctr.ru

Сайт https://muctr.ru
Уровень образования Высшее
Квалификация

Химик-технолог

Преподаваемые дисциплины

Методы энзимологии

Современные проблемы медицинской и фармацевтической биотехнологии

Учёная степень

Доктор технических наук

Наименование направления подготовки и (или) специальности

Технология неорганических веществ и химических удобрений

Общий стаж работы 11 лет (с 01.09.2007)
Стаж работы по специальности 11 лет (с 01.09.2007)

Публикации

Влияние высушивания и сроков хранения на свойства хитозановых композитов / А. А. Ванюшенкова, Э. Э. Досадина, А. А. Ханафина и др. // Бутлеровские сообщения . — 2019. — Т. 57, № 2. — С. 130–143.

Влияние хитозана на деструкцию целлюлозных носителей и кинетику выхода терапевтического агента в модельной среде / А. А. Ванюшенкова, Э. Э. Досадина, С. В. Каленов и др. // Бутлеровские сообщения . — 2019. — Т. 57, № 3. — С. 105–119.

Физиологические свойства резистентного штамма fusarium oxysporum / А. Г. Буланов, А. А. Шагаев, А. А. Белов, Н. С. Марквичев // Бутлеровские сообщения . — 2019. — Т. 57, № 2. — С. 144–150.

Formulation and production of a novel pharmaceutical substance for treatment of infected wounds - a chitosan chymopsin complex / A. A. Belov, L. L. Brkich, G. E. Brkich et al. // Journal of Pharmaceutical Sciences and Research . — 2018. — Vol. 10, no. №6. — P. 1310–1313. Abstract Wound infection represent a serious threat to wounded patients all over the world. Untreated wounds may result in bacterial wound infections, such as gas gangrene and tetanus. These in turn may lead to long term disabilities, chronic wound or bone infection, and, ultimately, death. Appropriate management of infected wounds is important to reduce the likelihood of life-threatening complications. Chitosan chymopsin complex (CCC) is a novel pharmaceutical substance consisting of chymopsin (a combination of two proteolytic enzymes: trypsin and chymotrypsin) and acid-soluble chitosan (a natural high molecular weight polysaccharide). This substance, either alone or together with antiseptic and/or anesthetic agents, can be used in treatment of infected wounds of different etiology. Synthesis, and production of active pharmaceutical ingredients (API) using biotechnological methods are the most demanding and costly stages of drug manufacturing. Therefore, a thoughtfully performed formulation can significantly reduce production costs, make manufacturing less labour-intensive, and, of course, improve API performance and quality. The paper describes the process of formulation of a novel API which possesses complex therapeutical activity, allows for faster wound healing and effective clearance of wound surface from pus and necrotic debris. Keywords: active pharmaceutical ingredient, chitin deacetylation, chitosan chymopsin complex (ССС), crab hepatopancreas, infected wounds treatment, polyelectrolyte complex (PEC), proteolytic complex (PC), proteolytic unit (PU).

Halobacterium salinarum storage and rehydration after spray drying and optimization of the processes for preservation of carotenoids / S. V. Kalenov, M. G. Gordienko, E. D. Murzina et al. // Extremophiles . — 2018. — Vol. 22, no. 3. — P. 511–523. Spray drying is appropriate for the preservation of halophilic microorganisms due to the nature of these microorganisms, as they survive in adverse environmental conditions by being encapsulated in salt crystals. Artificial neural networks were in this study used to optimize practically significant spray-drying regimes of the C50-carotenoids producer Halobacterium salinarum. Immediately after drying, the samples contained up to 54% halobacterial biomass and less than 5% moisture, and the level of preservation of carotenoids was 95–97%. The storage of biomass at 4 oC resulted in the gradual degradation of the carotenoids, which reached 58–64% in the best samples after 1 year. A comprehensive study of changes in halobacteria biomass after spray drying and the nature of the damage provided new data on the survival and preservation of cells and biologically active substances in the various spray-drying regimes and at different storage times. [ DOI ]

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